THE EFFECT OF DEFASCICULATING DOSES OF PANCURONIUM AND ATRACURIUM ON SUCCINYLCHOLINE NEUROMUSCULAR BLOCKADE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOTAMED CYRUS; PHILIPPE DUVALDESTIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Anesthesiology and Pain Medicine Year:2014 | Volume:4 | Issue:4 Page(s): 0-0

Download Full-Text

View:

270

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF DEFASCICULATING DOSES OF PANCURONIUM AND ATRACURIUM ON SUCCINYLCHOLINE NEUROMUSCULAR BLOCKADE

Author(s)

MOTAMED CYRUS | PHILIPPE DUVALDESTIN | Issue Writer Certificate

Keywords

SUCCINYLCHOLINE

ATRACURIUM

PANCURONIUM

Abstract

Background: A defasciculating dose of non-depolarizing muscle relaxant administered prior SUCCINYLCHOLINE decrease its side effects including fasciculations and postoperative myalgias; however it is believed that the dosage of SUCCINYLCHOLINE should be increased when such a pre-treatment is used.Objectives: We hypothesized that a defasciculating dose of PANCURONIUM as a pre-treatment could prolong its duration of effect.Patients and Methods: Forty patients scheduled for elective orthopaedic surgery were consecutively assigned into 5 groups, a first group without pre-treatment (SUCCINYLCHOLINE 1 mg/kg) and 4 subsequent groups of pretreatment with ATRACURIUM 0.05 mg/kg+SUCCINYLCHOLINE 1 or 1.5 mg/kg and PANCURONIUM 7.5 mg/kg+SUCCINYLCHOLINE 1 and 1.5 mg/kg. The muscle relaxant effect of SUCCINYLCHOLINE was assessed with a force transducer using train of four stimulations every 12 seconds. Kruskall Wallis Anova test was used to compare results.Results: The duration of SUCCINYLCHOLINE induced paralysis (1 and 1.5 mg/kg) was significantly prolonged with pre-treatment with PANCURONIUM but SUCCINYLCHOLINE 1mg/kg did not reached maximum blockade after pre-treatment with ATRACURIUM. After PANCURONIUM, full recovery after SUCCINYLCHOLINE 1.5 and 1 mg/kg occurred respectively after 18 and 15 minutes. P<0.05 vs.12 minutes for SUCCINYLCHOLINE 1mg/kg alone.Conclusions: This study highlights potentiation effect of a defasciculating dose of PANCURONIUM on SUCCINYLCHOLINE paralysis suggesting the lack of justification to increase SUCCINYLCHOLINE dosage.

Cites

No record.

References

No record.

Cite

APA: Copy

MOTAMED, CYRUS, & PHILIPPE, DUVALDESTIN. (2014). THE EFFECT OF DEFASCICULATING DOSES OF PANCURONIUM AND ATRACURIUM ON SUCCINYLCHOLINE NEUROMUSCULAR BLOCKADE. ANESTHESIOLOGY AND PAIN MEDICINE, 4(4), 0-0. SID. https://sid.ir/paper/328469/en

Vancouver: Copy

MOTAMED CYRUS, PHILIPPE DUVALDESTIN. THE EFFECT OF DEFASCICULATING DOSES OF PANCURONIUM AND ATRACURIUM ON SUCCINYLCHOLINE NEUROMUSCULAR BLOCKADE. ANESTHESIOLOGY AND PAIN MEDICINE[Internet]. 2014;4(4):0-0. Available from: https://sid.ir/paper/328469/en

IEEE: Copy

CYRUS MOTAMED, and DUVALDESTIN PHILIPPE, “THE EFFECT OF DEFASCICULATING DOSES OF PANCURONIUM AND ATRACURIUM ON SUCCINYLCHOLINE NEUROMUSCULAR BLOCKADE,” ANESTHESIOLOGY AND PAIN MEDICINE, vol. 4, no. 4, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/328469/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops