THE EFFECT OF DEFASCICULATING DOSES OF PANCURONIUM AND ATRACURIUM ON SUCCINYLCHOLINE NEUROMUSCULAR BLOCKADE

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MOTAMED CYRUS; PHILIPPE DUVALDESTIN

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Journal: Anesthesiology and Pain Medicine Year:2014 | Volume:4 | Issue:4 Page(s): 0-0

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Title

THE EFFECT OF DEFASCICULATING DOSES OF PANCURONIUM AND ATRACURIUM ON SUCCINYLCHOLINE NEUROMUSCULAR BLOCKADE

Author(s)

MOTAMED CYRUS | PHILIPPE DUVALDESTIN | Issue Writer Certificate

Keywords

SUCCINYLCHOLINE

ATRACURIUM

PANCURONIUM

Abstract

Background: A defasciculating dose of non-depolarizing muscle relaxant administered prior SUCCINYLCHOLINE decrease its side effects including fasciculations and postoperative myalgias; however it is believed that the dosage of SUCCINYLCHOLINE should be increased when such a pre-treatment is used.Objectives: We hypothesized that a defasciculating dose of PANCURONIUM as a pre-treatment could prolong its duration of effect.Patients and Methods: Forty patients scheduled for elective orthopaedic surgery were consecutively assigned into 5 groups, a first group without pre-treatment (SUCCINYLCHOLINE 1 mg/kg) and 4 subsequent groups of pretreatment with ATRACURIUM 0.05 mg/kg+SUCCINYLCHOLINE 1 or 1.5 mg/kg and PANCURONIUM 7.5 mg/kg+SUCCINYLCHOLINE 1 and 1.5 mg/kg. The muscle relaxant effect of SUCCINYLCHOLINE was assessed with a force transducer using train of four stimulations every 12 seconds. Kruskall Wallis Anova test was used to compare results.Results: The duration of SUCCINYLCHOLINE induced paralysis (1 and 1.5 mg/kg) was significantly prolonged with pre-treatment with PANCURONIUM but SUCCINYLCHOLINE 1mg/kg did not reached maximum blockade after pre-treatment with ATRACURIUM. After PANCURONIUM, full recovery after SUCCINYLCHOLINE 1.5 and 1 mg/kg occurred respectively after 18 and 15 minutes. P<0.05 vs.12 minutes for SUCCINYLCHOLINE 1mg/kg alone.Conclusions: This study highlights potentiation effect of a defasciculating dose of PANCURONIUM on SUCCINYLCHOLINE paralysis suggesting the lack of justification to increase SUCCINYLCHOLINE dosage.

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APA: Copy

MOTAMED, CYRUS, & PHILIPPE, DUVALDESTIN. (2014). THE EFFECT OF DEFASCICULATING DOSES OF PANCURONIUM AND ATRACURIUM ON SUCCINYLCHOLINE NEUROMUSCULAR BLOCKADE. ANESTHESIOLOGY AND PAIN MEDICINE, 4(4), 0-0. SID. https://sid.ir/paper/328469/en

Vancouver: Copy

MOTAMED CYRUS, PHILIPPE DUVALDESTIN. THE EFFECT OF DEFASCICULATING DOSES OF PANCURONIUM AND ATRACURIUM ON SUCCINYLCHOLINE NEUROMUSCULAR BLOCKADE. ANESTHESIOLOGY AND PAIN MEDICINE[Internet]. 2014;4(4):0-0. Available from: https://sid.ir/paper/328469/en

IEEE: Copy

CYRUS MOTAMED, and DUVALDESTIN PHILIPPE, “THE EFFECT OF DEFASCICULATING DOSES OF PANCURONIUM AND ATRACURIUM ON SUCCINYLCHOLINE NEUROMUSCULAR BLOCKADE,” ANESTHESIOLOGY AND PAIN MEDICINE, vol. 4, no. 4, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/328469/en

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