ATTENUATION OF CISPLATHIN-INDUCED TOXIC OXIDATIVE STRESS BY PROPOFOL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAHERI MOGHADAM GHAZALEH; HOSSEINI ZIJOUD SEYED MOSTAFA; HEIDARY SHAYESTEH TAVAKOL; GHASEMI HASAN; RANJBAR AKRAM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Anesthesiology and Pain Medicine Year:2014 | Volume:4 | Issue:4 Page(s): 0-0

Download Full-Text

View:

337

Download:

Cites:

Information Journal Paper

Title

ATTENUATION OF CISPLATHIN-INDUCED TOXIC OXIDATIVE STRESS BY PROPOFOL

Author(s)

Keywords

PROPOFOL

CISPLATIN

OXIBDATIVE STRESS

RAT

Abstract

Background: Antioxidant effects of PROPOFOL (2, 6-diisopropylphenol) were evaluated against CISPLATIN-induced oxidative stress in RAT.Objectives: In this experimental study, 20 male RATs were equally divided into 4 groups (5 RATs each), and were treated by PROPOFOL (10 mg/kg/day, IP), or CISPLATIN (7 mg /kg/day, IP), or both.Materials and Methods: Group one was control, while group 2 was given CISPLATIN (7 mg /kg/day, IP). Animals of the third group received only PROPOFOL (10 mg/kg/day, IP). Group 4 was given PROPOFOL with CISPLATIN once per day for 7 days. After treatment, blood urea nitrogen, creatinine levels, and oxidative stress m arkers such as total thiol groups (TTG), lipid peroxidation (LPO), and total antioxidant capacity (TAC) were measured.Results: Oxidative stress induced by CISPLATIN, was evident by a significant increase in LPO and decrease in TTG and TAC. PROPOFOL recovered CISPLATIN-induced changes in TAC, TTG and LPO in blood.Conclusions: It is concluded that oxidative damage is the mechanism of CISPLATIN toxicity, which can be recovered by PROPOFOL.

Cites

References

No record.

Cite

APA: Copy

TAHERI MOGHADAM, GHAZALEH, HOSSEINI ZIJOUD, SEYED MOSTAFA, HEIDARY SHAYESTEH, TAVAKOL, GHASEMI, HASAN, & RANJBAR, AKRAM. (2014). ATTENUATION OF CISPLATHIN-INDUCED TOXIC OXIDATIVE STRESS BY PROPOFOL. ANESTHESIOLOGY AND PAIN MEDICINE, 4(4), 0-0. SID. https://sid.ir/paper/328473/en

Vancouver: Copy

TAHERI MOGHADAM GHAZALEH, HOSSEINI ZIJOUD SEYED MOSTAFA, HEIDARY SHAYESTEH TAVAKOL, GHASEMI HASAN, RANJBAR AKRAM. ATTENUATION OF CISPLATHIN-INDUCED TOXIC OXIDATIVE STRESS BY PROPOFOL. ANESTHESIOLOGY AND PAIN MEDICINE[Internet]. 2014;4(4):0-0. Available from: https://sid.ir/paper/328473/en

IEEE: Copy

GHAZALEH TAHERI MOGHADAM, SEYED MOSTAFA HOSSEINI ZIJOUD, TAVAKOL HEIDARY SHAYESTEH, HASAN GHASEMI, and AKRAM RANJBAR, “ATTENUATION OF CISPLATHIN-INDUCED TOXIC OXIDATIVE STRESS BY PROPOFOL,” ANESTHESIOLOGY AND PAIN MEDICINE, vol. 4, no. 4, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/328473/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops