مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

INTRAVENOUS PATIENT-CONTROLLED REMIFENTANIL VERSUS PARACETAMOL IN POST-OPERATIVE PAIN MANAGEMENT IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFT SURGERY

Pages

  1-6

Abstract

 Background: Pain management after CARDIAC SURGERY has been based on parenteral long-acting opioids such as morphine. The other alternatives are paracetamol and REMIFENTANIL.Objectives: In this prospective, double-blind, randomized study, we compared the efficacy of intravenous PATIENT-CONTROLLED ANALGESIA (IV-PCA) paracetamol and REMIFENTANIL for post CARDIAC SURGERY pain relief.Materials and Methods: One-hundred patients scheduled for elective coronary artery bypass grafting from May to October 2011, were randomized into two groups after the surgery. For the first group (group R, n=50, with mean age of 58.16±11.80), the IV-PCA protocol was REMIFENTANIL infusion 100 mg/h; bolus of 25 mg and lockout time of 15 minutes. In the second group (group P, n=50, with mean age of 53.8±15.08), patients received paracetamol 15 mg/kg as a bolus at the end of surgery and then IV-PCA protocol was 100 mg/h, bolus of 25 mg; and lockout time of 15 minutes. Pain was assessed with visual analog scale score (VAS) in the first 24 hours after surgery for seven times.Results: The trend of pain scores did not have any significantly difference between group R and group P except for hour 8 and hour 18 after surgery that VAS was significantly lower in group P than group R (P=0.031, P=0.023, respectively). Respiratory rate (RR) was also statistically lower in group R comparing to group P in all seven evaluating times. The groups were similar in terms of hemodynamic, ABG results (except for PaO2, which was significantly lower in group R than group P at 6 evaluating times), intubation time, renal function tests, and incidences of atelectasis, myocardial infarction or adverse effects.Conclusions: Both PCA techniques provided effective pain scores (<3) after CARDIAC SURGERY; but generally, PCA-paracetamol infusion has a better analgesic effect.

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    APA: Copy

    JAHANGIRI FARD, ALIREZA, BABAEE, TOURAJ, ALAVI, SEYED MOSTAFA, NASIRI, ALI AKBAR, GHOREISHI, SEYED MOHAMAD MEHRAN, NOORI, NOOR MOHAMMAD, & MAHJOUBIFARD, MAZIAR. (2014). INTRAVENOUS PATIENT-CONTROLLED REMIFENTANIL VERSUS PARACETAMOL IN POST-OPERATIVE PAIN MANAGEMENT IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFT SURGERY. ANESTHESIOLOGY AND PAIN MEDICINE, 4(5), 1-6. SID. https://sid.ir/paper/328532/en

    Vancouver: Copy

    JAHANGIRI FARD ALIREZA, BABAEE TOURAJ, ALAVI SEYED MOSTAFA, NASIRI ALI AKBAR, GHOREISHI SEYED MOHAMAD MEHRAN, NOORI NOOR MOHAMMAD, MAHJOUBIFARD MAZIAR. INTRAVENOUS PATIENT-CONTROLLED REMIFENTANIL VERSUS PARACETAMOL IN POST-OPERATIVE PAIN MANAGEMENT IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFT SURGERY. ANESTHESIOLOGY AND PAIN MEDICINE[Internet]. 2014;4(5):1-6. Available from: https://sid.ir/paper/328532/en

    IEEE: Copy

    ALIREZA JAHANGIRI FARD, TOURAJ BABAEE, SEYED MOSTAFA ALAVI, ALI AKBAR NASIRI, SEYED MOHAMAD MEHRAN GHOREISHI, NOOR MOHAMMAD NOORI, and MAZIAR MAHJOUBIFARD, “INTRAVENOUS PATIENT-CONTROLLED REMIFENTANIL VERSUS PARACETAMOL IN POST-OPERATIVE PAIN MANAGEMENT IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFT SURGERY,” ANESTHESIOLOGY AND PAIN MEDICINE, vol. 4, no. 5, pp. 1–6, 2014, [Online]. Available: https://sid.ir/paper/328532/en

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