INVESTIGATION OF SERA CONTENT OF GLUTATHIONE-S-TRANSFERASE-Π IN GASTRIC AND ESOPHAGEAL CANCEROUS PATIENTS

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ZARE A.; ALAMEH A.A.; RASSAEE M.J.; NAGHIBI H.R.

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Journal: KOWSAR MEDICAL JOURNAL Year:2000 | Volume:5 | Issue:Part 1 Page(s): 11-16

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Information Journal Paper

Title

INVESTIGATION OF SERA CONTENT OF GLUTATHIONE-S-TRANSFERASE-Π IN GASTRIC AND ESOPHAGEAL CANCEROUS PATIENTS

Author(s)

ZARE A. | ALAMEH A.A. | RASSAEE M.J. | NAGHIBI H.R. | Issue Writer Certificate

Keywords

GLUTATHIONE-S-TRANSFERASEQ4

GASTRIC-ESOPHAGEAL CANCERQ2

BIOMARKERQ3

ELISAQ3

Abstract

GLUTATHIONE-S-TRANSFERASEs (GSTs) have been shown to be involved in the cellular detoxification of endogen and exogenous compounds. The human placental form (GSTπ) has recently been suggested to be a marker of carcinogenesis. In the present study we have investigated the sera content of GST-π as a diagnostic factor in patients with malignancies. The first enzyme immunoassay for GST -π determination was developed. The range of dose dependent curve was 0.4-20 ng/ml without cross reactivity with other isoenzymes. By using developed ELISA method, sera level of GST-π in 42 normal subjects and gastric and esophageal patients were (10.3±2.9, 23.7±5.4 and 22.8±3.5 ng/ml respectively (P<0.001). Over 80% of patients with stage IV gastric cancer and 75% of esophageal patients with stage IV and even about 60% of those with stage II,III and about 60% of gastric patients with stage II had elevated serum GST-π.

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APA: Copy

ZARE, A., ALAMEH, A.A., RASSAEE, M.J., & NAGHIBI, H.R.. (2000). INVESTIGATION OF SERA CONTENT OF GLUTATHIONE-S-TRANSFERASE-Π IN GASTRIC AND ESOPHAGEAL CANCEROUS PATIENTS. KOWSAR MEDICAL JOURNAL, 5(Part 1), 11-16. SID. https://sid.ir/paper/32855/en

Vancouver: Copy

ZARE A., ALAMEH A.A., RASSAEE M.J., NAGHIBI H.R.. INVESTIGATION OF SERA CONTENT OF GLUTATHIONE-S-TRANSFERASE-Π IN GASTRIC AND ESOPHAGEAL CANCEROUS PATIENTS. KOWSAR MEDICAL JOURNAL[Internet]. 2000;5(Part 1):11-16. Available from: https://sid.ir/paper/32855/en

IEEE: Copy

A. ZARE, A.A. ALAMEH, M.J. RASSAEE, and H.R. NAGHIBI, “INVESTIGATION OF SERA CONTENT OF GLUTATHIONE-S-TRANSFERASE-Π IN GASTRIC AND ESOPHAGEAL CANCEROUS PATIENTS,” KOWSAR MEDICAL JOURNAL, vol. 5, no. Part 1, pp. 11–16, 2000, [Online]. Available: https://sid.ir/paper/32855/en

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