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Information Journal Paper

Title

EFFECTIVE BOLUS DOSE OF SUFENTANIL TO ATTENUATE CARDIOVASCULAR RESPONSES IN LARYNGOSCOPIC DOUBLE-LUMEN ENDOBRONCHIAL INTUBATION

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Abstract

 Background: SUFENTANIL is a potent opioid analgesic frequently used in clinical anesthesia. Double-lumen endobronchial INTUBATION induces profound CARDIOVASCULAR responses in comparison with ordinary endotracheal INTUBATION because of the larger tube diameter and direct irritation of the carina.Objectives: The purpose of this study was to determine the effective bolus dose of SUFENTANIL to attenuate HEMODYNAMIC changes in response to laryngoscopic double-lumen endobronchial INTUBATION.Patients and Methods: We randomly assigned 72 patients aged 18 - 65 years and with an American Society of Anesthesiologists physical status of 1 or 2 to one of four SUFENTANIL dose groups: NS, S0.1, S0.2, or S0.3. The respective doses for the groups were as follows: normal saline, 0.1 mcg/kg of SUFENTANIL, 0.2 mcg/kg of SUFENTANIL, and0.3 mcg/kg of SUFENTANIL. Blood pressure andheart rate were recorded during the pre-anesthesia period at baseline, pre-intubation, immediate post-intubation, and every minute during 5 minutes after INTUBATION.Results: Baselinemeanarterial pressures in the NS, S0.1, S0.2, and S0.3 groups were 89.812.1, 89.210.9, 88.813.6, and 90.711.1, respectively. At immediate post-intubation, the mean arterial pressures in the NS, S0.1, S0.2, and S0.3 groups were 129.714.7, 120.7 14.2, 120.817.2, and 96.710.4, respectively. At immediate post-intubation, the mean arterial pressure in the NS, S0.1, and S0.2 groups significantly increased from baseline (P<0.001), but the S0.3 group showed no difference. In the time point comparison at immediate post- INTUBATION, the S0.3 group had a significantly lower mean arterial pressure than did the NS, S0.1, and S0.2 groups (P<0.001).Conclusions: We found that 0.3 mcg/kg of SUFENTANIL attenuates CARDIOVASCULAR responses to double-lumen endobronchial INTUBATION without adverse effects.

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    Cite

    APA: Copy

    CHOI, BYUNG HEE, & LEE, YONG CHEOL. (). . , (), -. SID. https://sid.ir/paper/328582/en

    Vancouver: Copy

    CHOI BYUNG HEE, LEE YONG CHEOL. . [Internet]. ;():-. Available from: https://sid.ir/paper/328582/en

    IEEE: Copy

    BYUNG HEE CHOI, and YONG CHEOL LEE, “,” , vol. , no. , pp. –, , [Online]. Available: https://sid.ir/paper/328582/en

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