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Information Journal Paper

Title

BLASTEMA CELLS DERIVED FROM RABBIT EAR SHOW STEM CELL CHARACTERISTICS

Pages

  25-31

Abstract

 REGENERATION is a biological phenomenon, which takes place via two main mechanisms: first, dedifferentiation of mature cells followed by their differentiation into functional new cells and second, activation of endogenous somatic STEM CELLs for REGENERATION of damaged or lost tissues. One of the best examples of healing process in mammals is the REGENERATION of damaged pinna in rabbits by BLASTEMA TISSUE.The aim of present study was to investigate culture requirements, proliferative properties and expression of some stemness factors in cells derived from regenerating BLASTEMA TISSUE obtained from rabbit pinnain vitro.The regenerating tissues were obtained from male New Zealand white rabbits by double punching of the pinna and cell culture conditions were set to derive and enrich the self renewing cells for further characterisation. The cells were subjected to survival and growth examinations in vitro, and expression of several stemness factors was studied in these cells using reverse transcription polymerase chain reaction (RT-PCR). Results revealed that the derived cells are rather immortal, as they have been growing for more than 120 passages in culture up until this report. Furthermore, RT-PCR and flow cytometry analyses showed that these cells express a number of stemness related genes includingOct4 and Sox2. In conclusion, in this study, stem like cells were derived from BLASTEMA TISSUE of rabbit ears for the first time, showing great self renewing capacity, which provides a suitablein vitro model for REGENERATION studies. Moreover, they could be considered as a good source of stem like cells for future applications.

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    APA: Copy

    MAHMOUDI, ZAHRA, MOGHADDAM MATIN, MARYAM, SAEINASAB, MORVARID, NAKHAEI RAD, SAEIDEH, MIRAHMADI, MAHDI, MAHDAVI SHAHRI, NASSER, MAHMOUDI, MAHMOUD, & BAHRAMI, AHMAD REZA. (2011). BLASTEMA CELLS DERIVED FROM RABBIT EAR SHOW STEM CELL CHARACTERISTICS. JOURNAL OF CELL AND MOLECULAR RESEARCH, 3(1), 25-31. SID. https://sid.ir/paper/329260/en

    Vancouver: Copy

    MAHMOUDI ZAHRA, MOGHADDAM MATIN MARYAM, SAEINASAB MORVARID, NAKHAEI RAD SAEIDEH, MIRAHMADI MAHDI, MAHDAVI SHAHRI NASSER, MAHMOUDI MAHMOUD, BAHRAMI AHMAD REZA. BLASTEMA CELLS DERIVED FROM RABBIT EAR SHOW STEM CELL CHARACTERISTICS. JOURNAL OF CELL AND MOLECULAR RESEARCH[Internet]. 2011;3(1):25-31. Available from: https://sid.ir/paper/329260/en

    IEEE: Copy

    ZAHRA MAHMOUDI, MARYAM MOGHADDAM MATIN, MORVARID SAEINASAB, SAEIDEH NAKHAEI RAD, MAHDI MIRAHMADI, NASSER MAHDAVI SHAHRI, MAHMOUD MAHMOUDI, and AHMAD REZA BAHRAMI, “BLASTEMA CELLS DERIVED FROM RABBIT EAR SHOW STEM CELL CHARACTERISTICS,” JOURNAL OF CELL AND MOLECULAR RESEARCH, vol. 3, no. 1, pp. 25–31, 2011, [Online]. Available: https://sid.ir/paper/329260/en

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