UNRAVELLING OVER-REPRESENTED AMINO ACIDS IN PROTEIN STRUCTURE OF ALLERGEN PROTEINS, A LARGE-SCALE STUDY

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RAHMANI NASSIM; EBRAHIMIE ESMAEIL; NIAZI ALI; Allahyari Fard Najaf; BAMBAI BIJAN; MINUCHEHR ZARRIN; EBRAHIMI MANSOUR

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Journal: JOURNAL OF CELL AND MOLECULAR RESEARCH Year:2016 | Volume:8 | Issue:2 Page(s): 65-70

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Title

UNRAVELLING OVER-REPRESENTED AMINO ACIDS IN PROTEIN STRUCTURE OF ALLERGEN PROTEINS, A LARGE-SCALE STUDY

Author(s)

Keywords

PLANT ALLERGENS

ATTRIBUTE WEIGHTING ALGORITHMS

AMINO ACID

Abstract

Allergens are proteins or glycoproteins which make widespread disorders that can lead to a systemic anaphylactic shock and even death within a short period of time. Understanding the protein features that are involved in allergenicity is important in developing future treatments as well as engineering proteins in genetic transformation projects. A big dataset of 1439 protein features from 761 PLANT ALLERGENS and 7815 non-allergen proteins was constructed. Thereafter, 10 different ATTRIBUTE WEIGHTING ALGORITHMS were utilized to find the key characteristics differentiating allergens and non-allergen proteins. The frequency of Leu, Arg and Gln selected by different ATTRIBUTE WEIGHTING ALGORITHMS with more than 50% confidence, including attribute weighting by Weight_Info Gain, Weight Chi Squared, Weight_Gini Index and Weight Relief. High amount of Gln and low percentage of Leu and Arg discriminate PLANT ALLERGENS from non-allergens.

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APA: Copy

RAHMANI, NASSIM, EBRAHIMIE, ESMAEIL, NIAZI, ALI, Allahyari Fard, Najaf, BAMBAI, BIJAN, MINUCHEHR, ZARRIN, & EBRAHIMI, MANSOUR. (2016). UNRAVELLING OVER-REPRESENTED AMINO ACIDS IN PROTEIN STRUCTURE OF ALLERGEN PROTEINS, A LARGE-SCALE STUDY. JOURNAL OF CELL AND MOLECULAR RESEARCH, 8(2), 65-70. SID. https://sid.ir/paper/329284/en

Vancouver: Copy

RAHMANI NASSIM, EBRAHIMIE ESMAEIL, NIAZI ALI, Allahyari Fard Najaf, BAMBAI BIJAN, MINUCHEHR ZARRIN, EBRAHIMI MANSOUR. UNRAVELLING OVER-REPRESENTED AMINO ACIDS IN PROTEIN STRUCTURE OF ALLERGEN PROTEINS, A LARGE-SCALE STUDY. JOURNAL OF CELL AND MOLECULAR RESEARCH[Internet]. 2016;8(2):65-70. Available from: https://sid.ir/paper/329284/en

IEEE: Copy

NASSIM RAHMANI, ESMAEIL EBRAHIMIE, ALI NIAZI, Najaf Allahyari Fard, BIJAN BAMBAI, ZARRIN MINUCHEHR, and MANSOUR EBRAHIMI, “UNRAVELLING OVER-REPRESENTED AMINO ACIDS IN PROTEIN STRUCTURE OF ALLERGEN PROTEINS, A LARGE-SCALE STUDY,” JOURNAL OF CELL AND MOLECULAR RESEARCH, vol. 8, no. 2, pp. 65–70, 2016, [Online]. Available: https://sid.ir/paper/329284/en

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