TOLERANCE AND CROSS-TOLERANCE BETWEEN MORPHINE AND NICOTINE FOR INDUCTION OF CONDITIONED PLACE PREFERENCE IN MICE

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SAHRAEI HEDAYAT; GHOSHOUNI H.; FARAJI N.; ROSTAMI P.; ZARINDAST M.R.; JALILI S.

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Journal: KOWSAR MEDICAL JOURNAL Year:2003 | Volume:7 | Issue:part 4 Page(s): 269-274

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Title

TOLERANCE AND CROSS-TOLERANCE BETWEEN MORPHINE AND NICOTINE FOR INDUCTION OF CONDITIONED PLACE PREFERENCE IN MICE

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Keywords

NICOTINEQ3

MORPHINEQ3

TOLERANCEQ3

CROSS-TOLERANCEQ4

MICEQ3

DRUG REWARDQ4

Abstract

In the present study, TOLERANCE and CROSS-TOLERANCE between MORPHINE and NICOTINE in mice for induction of conditioned place preference (CPP) have been investigated. MICE were treated subcutaneously with MORPHINE (12.5, 25 and 50 mg/kg) once daily for three days in order to produce TOLERANCE to MORPHINE and NICOTINE for induction of cpp. While injection of MORPHINE (5 mg/kg; s.c.) and/or NICOTINE (1 mg/kg; i.p.) in normal animals produced significant CPP, in MORPHINE tolerated MICE neither drug was effective. Intraperitoneal adminstration of NICOTINE (0.5, 1 and 2 mg/kg) three times a day for a period of 12 days also induced TOLERANCE. In conclusion, it can be suggested that NICOTINE and MORPHINE use for induction of CPP have interactions with each other.

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APA: Copy

SAHRAEI, HEDAYAT, GHOSHOUNI, H., FARAJI, N., ROSTAMI, P., ZARINDAST, M.R., & JALILI, S.. (2003). TOLERANCE AND CROSS-TOLERANCE BETWEEN MORPHINE AND NICOTINE FOR INDUCTION OF CONDITIONED PLACE PREFERENCE IN MICE. KOWSAR MEDICAL JOURNAL, 7(part 4), 269-274. SID. https://sid.ir/paper/32950/en

Vancouver: Copy

SAHRAEI HEDAYAT, GHOSHOUNI H., FARAJI N., ROSTAMI P., ZARINDAST M.R., JALILI S.. TOLERANCE AND CROSS-TOLERANCE BETWEEN MORPHINE AND NICOTINE FOR INDUCTION OF CONDITIONED PLACE PREFERENCE IN MICE. KOWSAR MEDICAL JOURNAL[Internet]. 2003;7(part 4):269-274. Available from: https://sid.ir/paper/32950/en

IEEE: Copy

HEDAYAT SAHRAEI, H. GHOSHOUNI, N. FARAJI, P. ROSTAMI, M.R. ZARINDAST, and S. JALILI, “TOLERANCE AND CROSS-TOLERANCE BETWEEN MORPHINE AND NICOTINE FOR INDUCTION OF CONDITIONED PLACE PREFERENCE IN MICE,” KOWSAR MEDICAL JOURNAL, vol. 7, no. part 4, pp. 269–274, 2003, [Online]. Available: https://sid.ir/paper/32950/en

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