A STUDY OF THE INHIBITORY EFFECTS OF NICOTINE ON THE EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE

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SAHRAEI HEDAYAT; GHOLAMI A.; GHOSHOUNI H.; HAERI ROUHANI SEYED ALI; ZARDOUZ H.

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Journal: Pathobiology Research Year:2004 | Volume:7 | Issue:1 Page(s): 61-68

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Title

A STUDY OF THE INHIBITORY EFFECTS OF NICOTINE ON THE EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE

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Keywords

MORPHINEQ3

NICOTINEQ3

CONDITIONED PLACE PREFERENCEQ4

MICEQ3

ATROPHINEQ2

HEXAMETHONIUMQ4

Abstract

Purpose: In the present study, the effects of NICOTINE on the expression of conditioned place referenced (CPP) induced by MORPHINE in MICE have been investigated.Materials and Methods: Male albino MICE (W: 20-25gr) were used in this study and the CONDITIONED PLACE PREFERENCE was induced by the Carr method.Results: Subcutaneous (s.c) injection of MORPHINE (5 mg/kg) can produce a place preference. Furthermore, intrepretoneal (i.p.) (0.0025, 0.005 and 0.01 mg/kg) and intracerebroventricular (i.c.v) (0.003, 0.1 and 0.3 ng/mice) administration of NICOTINE significantly decreases the expression of CPP induced by MORPHINE. However, NICOTINE alone in the mentioned doses doesn't cause motivational effects. It appears that the i.c.v preadministration of the animals with peripheral nicotinic acethyiecholine receptor antagonist, HEXAMETHONIUM (0.03, 0.1 and 0.3 mg/mice; 10 min before NICOTINE) but not with i.p. HEXAMETHONIUM (1, 5 and 10 mg/kg; 30 min before NICOTINE), diminishes the effects of NICOTINE on MORPHINE induced CPP. This result was not observed for the i.c.v and i.p injection of atropine (as muscarinic acethylecholine receptor antagonist). The antagonists themselves, neither showed any motivational effects when used alone nor affected the expression of MORPHINE induced CPP.Conclusion: In conclusion, it appears that central NICOTINE receptor mechanism(s) may be involved in the expression of the CPP induced by MORPHINE.

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APA: Copy

SAHRAEI, HEDAYAT, GHOLAMI, A., GHOSHOUNI, H., HAERI ROUHANI, SEYED ALI, & ZARDOUZ, H.. (2004). A STUDY OF THE INHIBITORY EFFECTS OF NICOTINE ON THE EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE . PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 7(1), 61-68. SID. https://sid.ir/paper/81234/en

Vancouver: Copy

SAHRAEI HEDAYAT, GHOLAMI A., GHOSHOUNI H., HAERI ROUHANI SEYED ALI, ZARDOUZ H.. A STUDY OF THE INHIBITORY EFFECTS OF NICOTINE ON THE EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE . PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2004;7(1):61-68. Available from: https://sid.ir/paper/81234/en

IEEE: Copy

HEDAYAT SAHRAEI, A. GHOLAMI, H. GHOSHOUNI, SEYED ALI HAERI ROUHANI, and H. ZARDOUZ, “A STUDY OF THE INHIBITORY EFFECTS OF NICOTINE ON THE EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE ,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 7, no. 1, pp. 61–68, 2004, [Online]. Available: https://sid.ir/paper/81234/en

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