EFFECT OF PRE-TREATMENT WITH PHENYLEPHRINE ON CARDIAC ENZYMES IN REGIONAL ISCHEMIA/REPERFUSION IN THE ISOLATED RAT HEART

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FAGHIHI MAHDIEH; IMANI A.R.; NADERI ROUYA

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Journal: KOWSAR MEDICAL JOURNAL Year:2010 | Volume:14 | Issue:4 Page(s): 189-195

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Title

EFFECT OF PRE-TREATMENT WITH PHENYLEPHRINE ON CARDIAC ENZYMES IN REGIONAL ISCHEMIA/REPERFUSION IN THE ISOLATED RAT HEART

Author(s)

FAGHIHI MAHDIEH | IMANI A.R. | NADERI ROUYA | Issue Writer Certificate

Keywords

ISCHEMIA/REPERFUSIONQ3

PHENYLEPHRINEQ3

LACTATE DEHYDROGENASEQ2

CREATINE KINASEQ3

MITOCHONDRIUMQ2

Abstract

Aims: Although reperfusion is a valuable method for the survival of ischemic heart, it has additional deleterious effects. The aim of this study was to evaluate the preconditioning effect of PHENYLEPHRINE on ISCHEMIA/REPERFUSION (I/R) injury and to assess the role of mitochondrial ATP-sensitive K+ channels (mitoKATP) and permeability transition pore (mPTP) in rat heart.Materials & Methods: Anesthetized rat heart was isolated and perfused with Krebs buffer in Langendorff apparatus. In control group, only the surgery procedure was performed. In second group, 30 minutes of regional ischemia followed by 60 minutes of reperfusion. In third group, PHENYLEPHRINE was perfused 10 min before I/R. Forth an fifth groups were like third but respectively received 5-HD (100 mmol/l) and Atr (20 mmol/l). In sixth group, PHENYLEPHRINE was injected intraperitoneally 24 hours before I/R. Seventh an eighth groups were like sixth but respectively received 5-HD and Atr. Results: Performing I/R cause the level of LDH (lactate dehydrogenase) and CKMB (creatine kinase-MB) heart enzymes to increase in the coronary effluent collected in 5 and 60 minutes of reperfusion. Preconditioning with PHENYLEPHRINE reduced the enzyme level and using 5-HD and Atr abolished the effect of PHENYLEPHRINE.Conclusion: PHENYLEPHRINE preconditioning induces early and late cardioprotection via opening of mitoKATP channel and inhibition of mPTP in the isolated rat hearts.

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APA: Copy

FAGHIHI, MAHDIEH, IMANI, A.R., & NADERI, ROUYA. (2010). EFFECT OF PRE-TREATMENT WITH PHENYLEPHRINE ON CARDIAC ENZYMES IN REGIONAL ISCHEMIA/REPERFUSION IN THE ISOLATED RAT HEART. KOWSAR MEDICAL JOURNAL, 14(4), 189-195. SID. https://sid.ir/paper/32983/en

Vancouver: Copy

FAGHIHI MAHDIEH, IMANI A.R., NADERI ROUYA. EFFECT OF PRE-TREATMENT WITH PHENYLEPHRINE ON CARDIAC ENZYMES IN REGIONAL ISCHEMIA/REPERFUSION IN THE ISOLATED RAT HEART. KOWSAR MEDICAL JOURNAL[Internet]. 2010;14(4):189-195. Available from: https://sid.ir/paper/32983/en

IEEE: Copy

MAHDIEH FAGHIHI, A.R. IMANI, and ROUYA NADERI, “EFFECT OF PRE-TREATMENT WITH PHENYLEPHRINE ON CARDIAC ENZYMES IN REGIONAL ISCHEMIA/REPERFUSION IN THE ISOLATED RAT HEART,” KOWSAR MEDICAL JOURNAL, vol. 14, no. 4, pp. 189–195, 2010, [Online]. Available: https://sid.ir/paper/32983/en

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