EFFECT OF WIN 55212-2 IN DIAZINON-INDUCED TOXCICITY AND ITS INTERACTION WITH N-METHYL-D-ASPARTATE RECEPTOR IN PC12 CELL LINE

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HASHEMI MANSOUREH; BAHRAMI FARIDEH; ASGARI ALI REZA; SAHRAEI HEDAYAT

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Journal: KOWSAR MEDICAL JOURNAL Year:2010 | Volume:14 | Issue:4 Page(s): 197-204

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Title

EFFECT OF WIN 55212-2 IN DIAZINON-INDUCED TOXCICITY AND ITS INTERACTION WITH N-METHYL-D-ASPARTATE RECEPTOR IN PC12 CELL LINE

Author(s)

HASHEMI MANSOUREH | BAHRAMI FARIDEH | ASGARI ALI REZA | SAHRAEI HEDAYAT | Issue Writer Certificate

Keywords

WIN 55Q3

212-2Q2

DIAZINONQ3

NMDQ3

PC12Q3

Abstract

Aims: In this study, the protective effect of WIN 55212-2 (CB1 receptor agonist) and its interaction with N-methyl-D-aspartate receptor in DIAZINON-induced toxcicity in PC12 cells was evalued.Materials & Methods: In this study, PC12 maintained in DMEM+F12 culture medium supplemented with 10% fetal bovin serum. The cells were treated with DIAZINON (200 mM) in the presence or absence of WIN 55212-2 (0.1 mM), NMDA (100 mM), AM251 and MK801 (1 mM) in 15 minutes intervals. After 48 hours of exposure, cells viability and morphology were evaluated by MTS kit and invert light microscope, respectively.Results: Following the exposure of PC12 cells to DIAZINON (200 mM), a reduction in cell survival was observed (p<0.001). Treatment of the cells with WIN 55212-2 (0.1 mM) and NMDA (100 mM) prior to DIAZINON exposure, significantly elevated cell survival (p<0.01). Also, AM 251 (1 mM) did not inhibit cell survival increase induced by WIN 55212-2 (P<0.001). However, MK801(1 mM) inhibited cell survival increase induced by NMDA (p<0.001). Conclusion: WIN 55212-2 and NMDA protect PC12 cells against DIAZINONinduced toxicity.

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APA: Copy

HASHEMI, MANSOUREH, BAHRAMI, FARIDEH, ASGARI, ALI REZA, & SAHRAEI, HEDAYAT. (2010). EFFECT OF WIN 55212-2 IN DIAZINON-INDUCED TOXCICITY AND ITS INTERACTION WITH N-METHYL-D-ASPARTATE RECEPTOR IN PC12 CELL LINE. KOWSAR MEDICAL JOURNAL, 14(4), 197-204. SID. https://sid.ir/paper/32988/en

Vancouver: Copy

HASHEMI MANSOUREH, BAHRAMI FARIDEH, ASGARI ALI REZA, SAHRAEI HEDAYAT. EFFECT OF WIN 55212-2 IN DIAZINON-INDUCED TOXCICITY AND ITS INTERACTION WITH N-METHYL-D-ASPARTATE RECEPTOR IN PC12 CELL LINE. KOWSAR MEDICAL JOURNAL[Internet]. 2010;14(4):197-204. Available from: https://sid.ir/paper/32988/en

IEEE: Copy

MANSOUREH HASHEMI, FARIDEH BAHRAMI, ALI REZA ASGARI, and HEDAYAT SAHRAEI, “EFFECT OF WIN 55212-2 IN DIAZINON-INDUCED TOXCICITY AND ITS INTERACTION WITH N-METHYL-D-ASPARTATE RECEPTOR IN PC12 CELL LINE,” KOWSAR MEDICAL JOURNAL, vol. 14, no. 4, pp. 197–204, 2010, [Online]. Available: https://sid.ir/paper/32988/en

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