Immunogenicity and Efficacy of Polytope DNA Vaccine Against Cutaneous Leishmaniosis In Vivo

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Keikha Reza; BANDEHPOUR MOJGAN; JEIBOUEI Shabnam; KAZEMI BAHRAM

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Journal: Health Scope Year:2018 | Volume:7 | Issue:1 Page(s): 0-0

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Title

Immunogenicity and Efficacy of Polytope DNA Vaccine Against Cutaneous Leishmaniosis In Vivo

Author(s)

Keikha Reza | BANDEHPOUR MOJGAN | JEIBOUEI Shabnam | KAZEMI BAHRAM | Issue Writer Certificate

Keywords

Leishmaniosis

Epitopes

DNA Vaccine

LACK Antigen

GP63

Abstract

Background: About 12 million people are affected by les Leishmaniosis worldwide. It is an important public health problem due to the difficulty in its control and causing epidemic outbreaks. An effective anti-leishmanial vaccine remains elusive. Isolated dominant Epitopes arranged as polytope DNA Vaccine represent a promising approach. Methods: Balb/c mice were vaccinated subcutaneously with pCDNA3. 1/LAKJB93 DNA and challenged with Leishmania major promastigotes; then, the level of interferon (INF)- and interleukin (IL)-4 were measured by the enzyme-linked immunosorbent assay (ELISA) technique. Production of immunoglobulin (Ig)-G1 and IgG2a antigen specific antibodies were measured against LAKJB93. Results: The enhanced production of antigen-specific INF- and IgG2a in serum showed the stimulation of T helper type 1 (Th1) response. This protectiveimmune response was induced by the expression of pcDNA3. 1/ LAKJB93 plasmid against Leishmaniosis and therefore, pcDNA3. 1/ LAKJB93 can be considered an appropriate vaccine for Leishmaniosis. Conclusions: Immunization with DNA Vaccine may offer an effective route to prevent Leishmaniosis.

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APA: Copy

Keikha, Reza, BANDEHPOUR, MOJGAN, JEIBOUEI, Shabnam, & KAZEMI, BAHRAM. (2018). Immunogenicity and Efficacy of Polytope DNA Vaccine Against Cutaneous Leishmaniosis In Vivo. HEALTH SCOPE, 7(1), 0-0. SID. https://sid.ir/paper/330435/en

Vancouver: Copy

Keikha Reza, BANDEHPOUR MOJGAN, JEIBOUEI Shabnam, KAZEMI BAHRAM. Immunogenicity and Efficacy of Polytope DNA Vaccine Against Cutaneous Leishmaniosis In Vivo. HEALTH SCOPE[Internet]. 2018;7(1):0-0. Available from: https://sid.ir/paper/330435/en

IEEE: Copy

Reza Keikha, MOJGAN BANDEHPOUR, Shabnam JEIBOUEI, and BAHRAM KAZEMI, “Immunogenicity and Efficacy of Polytope DNA Vaccine Against Cutaneous Leishmaniosis In Vivo,” HEALTH SCOPE, vol. 7, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/330435/en

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