THE EFFECT OF ENOXAPARIN AND CLOPIDOGREL ON SURVIVAL OF RANDOM SKIN FLAP IN RAT ANIMAL MODEL

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FATEMI MOHAMMAD JAVAD; FOROOTAN KAMAL S.; S.JALALI SEYED ZIAADDIN; MOUSAVI SEYED JABER; PEDRAM MIRSEPEHR

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Journal: WORLD JOURNAL OF PLASTIC SURGERY Year:2012 | Volume:1 | Issue:2 Page(s): 64-70

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Title

THE EFFECT OF ENOXAPARIN AND CLOPIDOGREL ON SURVIVAL OF RANDOM SKIN FLAP IN RAT ANIMAL MODEL

Author(s)

Keywords

ENOXAPARIN

CLOPIDOGREL

SURVIVAL

SKIN FLAP

RAT

Abstract

BACKGROUND: Necrosis of SKIN FLAPs is considered as an important complication in reconstructive surgery. We conducted an experimental study to investigate the efficacy of low-molecular weight heparin, CLOPIDOGREL and their combination to improve the flap SURVIVAL.METHODS: Forty male, adult Sprague-Dawlay RATs were divided randomly into 4 groups. Standard rectangular, distally based dorsal random pattern SKIN FLAP was elevated. To prevent the graft effect, a sterile sheet was put under the flap. No pharmacological agent was administered for the control group. In group 2, single subcutaneous dose of ENOXAPARIN (3.2 mg/kg) was immediately administrated after surgery. In group 3, CLOPIDOGREL (25 mg/kg) was given orally for 7 days. In group 4, both ENOXAPARIN and CLOPIDOGREL were administrated. The RATs were evaluated on post-operative day 7 for viable and necrotic portions of flaps.RESULTS: The mean and SD of necrosis was 17.79 ±2.5 cm in the control group, 16.20±3.1 cm in low-molecular weight heparin, 15.25±3.8 cm in combined therapy group and 13.69±2.7 cm in CLOPIDOGREL group. CLOPIDOGREL was the only pharmaceutical agent that produced a significant increase in the flap SURVIVAL area.CONCLUSION: CLOPIDOGREL may be an effective pharmaceutical agent that significantly increases viability of random SKIN FLAPs in RATs, but low-molecular weight heparin and their combination did not have any significant beneficial effects.

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APA: Copy

FATEMI, MOHAMMAD JAVAD, FOROOTAN, KAMAL S., S.JALALI, SEYED ZIAADDIN, MOUSAVI, SEYED JABER, & PEDRAM, MIRSEPEHR. (2012). THE EFFECT OF ENOXAPARIN AND CLOPIDOGREL ON SURVIVAL OF RANDOM SKIN FLAP IN RAT ANIMAL MODEL. WORLD JOURNAL OF PLASTIC SURGERY, 1(2), 64-70. SID. https://sid.ir/paper/331082/en

Vancouver: Copy

FATEMI MOHAMMAD JAVAD, FOROOTAN KAMAL S., S.JALALI SEYED ZIAADDIN, MOUSAVI SEYED JABER, PEDRAM MIRSEPEHR. THE EFFECT OF ENOXAPARIN AND CLOPIDOGREL ON SURVIVAL OF RANDOM SKIN FLAP IN RAT ANIMAL MODEL. WORLD JOURNAL OF PLASTIC SURGERY[Internet]. 2012;1(2):64-70. Available from: https://sid.ir/paper/331082/en

IEEE: Copy

MOHAMMAD JAVAD FATEMI, KAMAL S. FOROOTAN, SEYED ZIAADDIN S.JALALI, SEYED JABER MOUSAVI, and MIRSEPEHR PEDRAM, “THE EFFECT OF ENOXAPARIN AND CLOPIDOGREL ON SURVIVAL OF RANDOM SKIN FLAP IN RAT ANIMAL MODEL,” WORLD JOURNAL OF PLASTIC SURGERY, vol. 1, no. 2, pp. 64–70, 2012, [Online]. Available: https://sid.ir/paper/331082/en

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