PROTECTIVE EFFECT OF PROSOPIS CINERARIA AGAINST N-NITROSODIETHYLAMINE INDUCED LIVER TUMOR BY MODULATING MEMBRANE BOUND ENZYMES AND GLYCOPROTEINS

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PAKKIR MAIDEEN NAINA MOHAMED; VELAYUTHAM RAVICHANDIRAN; MANAVALAN GOBINATH

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Journal: Advanced Pharmaceutical Bulletin Year:2012 | Volume:2 | Issue:2 Page(s): 179-182

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Title

PROTECTIVE EFFECT OF PROSOPIS CINERARIA AGAINST N-NITROSODIETHYLAMINE INDUCED LIVER TUMOR BY MODULATING MEMBRANE BOUND ENZYMES AND GLYCOPROTEINS

Author(s)

PAKKIR MAIDEEN NAINA MOHAMED | VELAYUTHAM RAVICHANDIRAN | MANAVALAN GOBINATH | Issue Writer Certificate

Keywords

PROSOPIS CINERARIA

LIVER TUMOR

N-NITROSODIETHYLAMINE

MEMBRANE BOUND ENZYMES

GLYCOPROTEINS

Abstract

Purpose: The objective of the present study was to evaluate the protective effect of methanol extract of PROSOPIS CINERARIA (MPC) against N-NITROSODIETHYLAMINE (DEN, 200 mg/kg) induced Phenobarbital promoted experimental LIVER TUMORs in male Wistar rats.Methods: The rats were divided into four groups, each group consisting of six animals. Group 1 served as control animals. LIVER TUMOR was induced in group 2, 3, and 4 and Group 3 animals received MPC 200 mg/kg and Group 4 animals received MPC 400 mg/kg.Results: Administration of DEN has brought down the levels of MEMBRANE BOUND ENZYMES like Na+/ K+ATPase, Mg2+ATPase and Ca2+ATPase which were later found to be increased by the administration of PROSOPIS CINERARIA (200 and 400 mg/kg) in dose dependent manner. The MPC extract also suppressed the levels of GLYCOPROTEINS like Hexose, Hexosamine and Sialic acid when compared to LIVER TUMOR bearing animals.Conclusions: Our study suggests that MPC may extend its protective role by modulating the levels of MEMBRANE BOUND ENZYMES and suppressing glycoprotein levels.

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APA: Copy

PAKKIR MAIDEEN, NAINA MOHAMED, VELAYUTHAM, RAVICHANDIRAN, & MANAVALAN, GOBINATH. (2012). PROTECTIVE EFFECT OF PROSOPIS CINERARIA AGAINST N-NITROSODIETHYLAMINE INDUCED LIVER TUMOR BY MODULATING MEMBRANE BOUND ENZYMES AND GLYCOPROTEINS. ADVANCED PHARMACEUTICAL BULLETIN, 2(2), 179-182. SID. https://sid.ir/paper/331664/en

Vancouver: Copy

PAKKIR MAIDEEN NAINA MOHAMED, VELAYUTHAM RAVICHANDIRAN, MANAVALAN GOBINATH. PROTECTIVE EFFECT OF PROSOPIS CINERARIA AGAINST N-NITROSODIETHYLAMINE INDUCED LIVER TUMOR BY MODULATING MEMBRANE BOUND ENZYMES AND GLYCOPROTEINS. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2012;2(2):179-182. Available from: https://sid.ir/paper/331664/en

IEEE: Copy

NAINA MOHAMED PAKKIR MAIDEEN, RAVICHANDIRAN VELAYUTHAM, and GOBINATH MANAVALAN, “PROTECTIVE EFFECT OF PROSOPIS CINERARIA AGAINST N-NITROSODIETHYLAMINE INDUCED LIVER TUMOR BY MODULATING MEMBRANE BOUND ENZYMES AND GLYCOPROTEINS,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 2, no. 2, pp. 179–182, 2012, [Online]. Available: https://sid.ir/paper/331664/en

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