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Information Journal Paper

Title

PHYTOCHEMICAL SCREENING AND ANTI-NOCICEPTIVE PROPERTIES OF THE ETHANOLIC LEAF EXTRACT OF TREMA CANNABINA LOUR

Pages

  103-108

Abstract

 Purpose: The present study was designed to investigate the ANTI-NOCICEPTIVE activity of ethanolic leaf extract of TREMA CANNABINA Lour (family: Cannabaceae) in experimental animal models.Methods: The ANTI-NOCICEPTIVE action was carried out against two types of noxious stimuli, thermal (hot plate and TAIL IMMERSION TESTs) and chemical (acetic acid-induced writhing) in mice.Results: Phytochemical analysis of crude extract indicated the presence of reducing sugar, tannins, steroid and alkaloid types of secondary metabolites. Crude extract of T. cannabina (500 mg/kg dose) showed maximum time needed for the response against thermal stimuli (6.79±0.15 seconds) which is comparable to diclofenac sodium (8.26±0.14 seconds) in the HOT PLATE TEST. Hot TAIL IMMERSION TEST also showed similar results as in HOT PLATE TEST. At the dose of 250 and 500 mg/kg body weight, the extract showed significantly and in a dose-dependent (p<0.001) reduction in acetic acid induced writhing in mice with a maximum effect of 47.56% reduction at 500 mg/kg dose comparable to that of diclofenac sodium (67.07%) at 25 mg/kg.Conclusion: The obtained results tend to suggest the ANTI-NOCICEPTIVE activity of ethanolic leaf extract of TREMA CANNABINA and thus provide the scientific basis for the traditional uses of this plant part as a remedy for pain.

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    APA: Copy

    HEMAYET, HOSSAIN, ARA JAHAN, ISMET, SARIFUL ISLAM, HOWLADER, SHUBHRA KANTI, DEY, ARPONA, HIRA, & ARIF, AHMED. (2013). PHYTOCHEMICAL SCREENING AND ANTI-NOCICEPTIVE PROPERTIES OF THE ETHANOLIC LEAF EXTRACT OF TREMA CANNABINA LOUR. ADVANCED PHARMACEUTICAL BULLETIN, 3(1), 103-108. SID. https://sid.ir/paper/331681/en

    Vancouver: Copy

    HEMAYET HOSSAIN, ARA JAHAN ISMET, SARIFUL ISLAM HOWLADER, SHUBHRA KANTI DEY, ARPONA HIRA, ARIF AHMED. PHYTOCHEMICAL SCREENING AND ANTI-NOCICEPTIVE PROPERTIES OF THE ETHANOLIC LEAF EXTRACT OF TREMA CANNABINA LOUR. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2013;3(1):103-108. Available from: https://sid.ir/paper/331681/en

    IEEE: Copy

    HOSSAIN HEMAYET, ISMET ARA JAHAN, HOWLADER SARIFUL ISLAM, DEY SHUBHRA KANTI, HIRA ARPONA, and AHMED ARIF, “PHYTOCHEMICAL SCREENING AND ANTI-NOCICEPTIVE PROPERTIES OF THE ETHANOLIC LEAF EXTRACT OF TREMA CANNABINA LOUR,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 3, no. 1, pp. 103–108, 2013, [Online]. Available: https://sid.ir/paper/331681/en

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