COMPARISON OF CYTOTOXIC ACTIVITY OF L778123 AS A FARNESYLTRANFERASE INHIBITOR AND DOXORUBICIN AGAINST A549 AND HT-29 CELL LINES

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GHASEMI SAEID; DAVARAN SOODABEH; SHARIFI SIMIN; ASGARI DAVOUD; ABD ELAHI ALI; SHAHBAZI MOJARRAD JAVID

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Journal: Advanced Pharmaceutical Bulletin Year:2013 | Volume:3 | Issue:1 Page(s): 73-77

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Title

COMPARISON OF CYTOTOXIC ACTIVITY OF L778123 AS A FARNESYLTRANFERASE INHIBITOR AND DOXORUBICIN AGAINST A549 AND HT-29 CELL LINES

Author(s)

Keywords

FARNESYLTRANSFERASE INHIBITOR

MTT ASSAY

COMBINATION THERAPY

L-778123

Abstract

Purpose: Farnesyltransferase (FTase) is a zinc-dependent enzyme that adds a farnesyl group to the Ras proteins. L778, 123 is a potent peptidomimetic imidazole-containing FTase inhibitor.Methods: L778123 was synthesized according to known methods and evaluated alone and in combination with doxorubicin against A549 (adenocarcinomic human alveolar basal epithelial cells) and HT29 (human colonic adenocarcinoma) cell lines by MTT ASSAY.Results: L778123 showed weak cytotoxic activity with IC50 of 100 and 125 for A549 and HT-29 cell lines, respectively. The combination of doxorubicin and L778123 can decrease IC50 of doxorubicin in both cell lines significantly.Conclusion: It can be concluded that L778, 123 can be a good agent for COMBINATION THERAPY.

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APA: Copy

GHASEMI, SAEID, DAVARAN, SOODABEH, SHARIFI, SIMIN, ASGARI, DAVOUD, ABD ELAHI, ALI, & SHAHBAZI MOJARRAD, JAVID. (2013). COMPARISON OF CYTOTOXIC ACTIVITY OF L778123 AS A FARNESYLTRANFERASE INHIBITOR AND DOXORUBICIN AGAINST A549 AND HT-29 CELL LINES. ADVANCED PHARMACEUTICAL BULLETIN, 3(1), 73-77. SID. https://sid.ir/paper/331685/en

Vancouver: Copy

GHASEMI SAEID, DAVARAN SOODABEH, SHARIFI SIMIN, ASGARI DAVOUD, ABD ELAHI ALI, SHAHBAZI MOJARRAD JAVID. COMPARISON OF CYTOTOXIC ACTIVITY OF L778123 AS A FARNESYLTRANFERASE INHIBITOR AND DOXORUBICIN AGAINST A549 AND HT-29 CELL LINES. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2013;3(1):73-77. Available from: https://sid.ir/paper/331685/en

IEEE: Copy

SAEID GHASEMI, SOODABEH DAVARAN, SIMIN SHARIFI, DAVOUD ASGARI, ALI ABD ELAHI, and JAVID SHAHBAZI MOJARRAD, “COMPARISON OF CYTOTOXIC ACTIVITY OF L778123 AS A FARNESYLTRANFERASE INHIBITOR AND DOXORUBICIN AGAINST A549 AND HT-29 CELL LINES,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 3, no. 1, pp. 73–77, 2013, [Online]. Available: https://sid.ir/paper/331685/en

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