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Information Journal Paper

Title

IN VITRO ANTIOXIDANT AND ANTICANCER ACTIVITY STUDIES ON DROSERA INDICA L. (DROSERACEAE)

Author(s)

 ASIRVATHAM RAJU | MARIA CHRISTINA AROCKIASAMY JOSPHIN | MURALI ANITA | Issue Writer Certificate 

Pages

  115-120

Keywords

DALTON’S ASCITIC LYMPHOMA (DAL) 
EHRLICH ASCITIC CARCINOMA (EAC) 

Abstract

 Purpose: The aim of present in vitro studies was performed to examine the antioxidant and anticancer activities of ethanol and aqueous extracts of DROSERA INDICA L.Methods: Different concentrations (5-640 mcg/ml) of the ethanol (EEDI) and aqueous (AEDI) extracts of D.indica L were used in various antioxidant assay methods such as hydroxyl radicals, DPPH, super oxide radical scavenging activity, chelating ability of ferrous ion, nitric oxide radical inhibition, ABTS and reducing power. Ascorbic acid (AA) was used as the standard antioxidant for the free radical scavenging assays. Dalton’s Ascitic Lymphoma (DAL) and Ehrlich Ascitic Carcinoma (EAC) cell lines were used as the in vitro cancer models for the tryphan blue dye and LDH leakage assays, where 5 to 250 mcg /ml of both EEDI and AEDI were tested.Results: EEDI showed antioxidant activities with the minimum IC50 values of 34.8±0.43 mcg/ml in scavenging of hydroxyl radical and moreover AEDI showed minimum IC50 values of 94.51±0.84 mcg/ml in Fe2+ chelating assay. EEDI on the reducing power assay and ABTS showed higher IC50 than standard AA. IC50 values of AEDI on Fe2+ chelating assay and super oxide radical assay was lesser than IC50 value of AA. Both extracts at 250 mcg/ml dose showed remarkable increase in the percentage of dead cancer cells (90% by EEDI and 86% by AEDI in DAL model and 89% by EEDI and 80% by AEDI in EAC model).Conclusion: It is concluded from this study that D.indica L exhibited excellent antioxidant activity against the different in vitro antioxidant models and ANTICANCER ACTIVITY against the two different cell lines tested.

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    APA: Copy

    ASIRVATHAM, RAJU, MARIA CHRISTINA, AROCKIASAMY JOSPHIN, & MURALI, ANITA. (2013). IN VITRO ANTIOXIDANT AND ANTICANCER ACTIVITY STUDIES ON DROSERA INDICA L. (DROSERACEAE). ADVANCED PHARMACEUTICAL BULLETIN, 3(1), 115-120. SID. https://sid.ir/paper/331687/en

    Vancouver: Copy

    ASIRVATHAM RAJU, MARIA CHRISTINA AROCKIASAMY JOSPHIN, MURALI ANITA. IN VITRO ANTIOXIDANT AND ANTICANCER ACTIVITY STUDIES ON DROSERA INDICA L. (DROSERACEAE). ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2013;3(1):115-120. Available from: https://sid.ir/paper/331687/en

    IEEE: Copy

    RAJU ASIRVATHAM, AROCKIASAMY JOSPHIN MARIA CHRISTINA, and ANITA MURALI, “IN VITRO ANTIOXIDANT AND ANTICANCER ACTIVITY STUDIES ON DROSERA INDICA L. (DROSERACEAE),” ADVANCED PHARMACEUTICAL BULLETIN, vol. 3, no. 1, pp. 115–120, 2013, [Online]. Available: https://sid.ir/paper/331687/en

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