INHIBITORY AND CYTOTOXIC ACTIVITIES OF SALVIA OFFICINALIS L. EXTRACT ON HUMAN LYMPHOMA AND LEUKEMIA CELLS BY INDUCTION OF APOPTOSIS

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ZARE SHAHNEH FATEMEH; VALIYARI SAMIRA; BARADARAN BEHZAD; ABD ALALI ZADEH JALAL; BANDEHAGH ALI; AZADMEHR ABBAS; HAJIAGHAEE REZA

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Journal: Advanced Pharmaceutical Bulletin Year:2013 | Volume:3 | Issue:1 Page(s): 51-55

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Title

INHIBITORY AND CYTOTOXIC ACTIVITIES OF SALVIA OFFICINALIS L. EXTRACT ON HUMAN LYMPHOMA AND LEUKEMIA CELLS BY INDUCTION OF APOPTOSIS

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Keywords

SALVIA OFFICINALIS L

CYTOTOXIC

ANTI-TUMOR

APOPTOSIS

CANCER

Abstract

Purpose: SALVIA OFFICINALIS L., also known as Maryam Goli, is one of the native plants used to Persian medicinal herbs. Hence, the objective of this study was to examine the in vitro CYTOTOXIC activities of a standardized crude methanol extracts prepared from SALVIA OFFICINALIS L., on a non-Hodgkin’s B-cell lymphoma (Raji) and human leukemic monocyte lymphoma (U937), Human acute myelocytic leukemia (KG-1A) and Human Umbilical Vein Endothelial (HUVEC) cell lines.Methods: The effect of methanolic extract on the inhibition of cell proliferation and CYTOTOXIC activity was evaluated by Dye exclusion and Micro culture tetrazolium test (MTT) CYTOTOXICity assay. Cell death ELISA was employed to quantify the nucleosome production result from nuclear DNA fragmentation during APOPTOSIS and determined whether the mechanism involves induction of APOPTOSIS or necrosis.Results: The present results demonstrated that methanolic extract at 50 to 800 mg/ml dose and time-dependently suppressed the proliferation of KG-1A, U937 and Raji cells by more than 80% (p<0.01), with ascending order of IC50 values in 24: KG-1A (214.377 mg/ml), U937 (229.312 mg/ml) and Raji (239.692 mg/ml) when compared with a chemotherapeutic anticancer drug, paclitaxel (Toxol), confirming the tumour-selective CYTOTOXICity. The crude extract however did not exert any significant CYTOTOXIC effect on normal cell line HUVEC (IC50>800 Ag/ml). Nucleosome productions in KG-1A, Raji and U937 cells were significantly increased respectively upon the treatment of SALVIA OFFICINALIS L. extract.Conclusion: The SALVIA OFFICINALIS L. extract was found dose and time-dependently inhibits the proliferation of lymphoma and leukemic cells possibly via an APOPTOSIS-dependent pathway.

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APA: Copy

ZARE SHAHNEH, FATEMEH, VALIYARI, SAMIRA, BARADARAN, BEHZAD, ABD ALALI ZADEH, JALAL, BANDEHAGH, ALI, AZADMEHR, ABBAS, & HAJIAGHAEE, REZA. (2013). INHIBITORY AND CYTOTOXIC ACTIVITIES OF SALVIA OFFICINALIS L. EXTRACT ON HUMAN LYMPHOMA AND LEUKEMIA CELLS BY INDUCTION OF APOPTOSIS. ADVANCED PHARMACEUTICAL BULLETIN, 3(1), 51-55. SID. https://sid.ir/paper/331704/en

Vancouver: Copy

ZARE SHAHNEH FATEMEH, VALIYARI SAMIRA, BARADARAN BEHZAD, ABD ALALI ZADEH JALAL, BANDEHAGH ALI, AZADMEHR ABBAS, HAJIAGHAEE REZA. INHIBITORY AND CYTOTOXIC ACTIVITIES OF SALVIA OFFICINALIS L. EXTRACT ON HUMAN LYMPHOMA AND LEUKEMIA CELLS BY INDUCTION OF APOPTOSIS. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2013;3(1):51-55. Available from: https://sid.ir/paper/331704/en

IEEE: Copy

FATEMEH ZARE SHAHNEH, SAMIRA VALIYARI, BEHZAD BARADARAN, JALAL ABD ALALI ZADEH, ALI BANDEHAGH, ABBAS AZADMEHR, and REZA HAJIAGHAEE, “INHIBITORY AND CYTOTOXIC ACTIVITIES OF SALVIA OFFICINALIS L. EXTRACT ON HUMAN LYMPHOMA AND LEUKEMIA CELLS BY INDUCTION OF APOPTOSIS,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 3, no. 1, pp. 51–55, 2013, [Online]. Available: https://sid.ir/paper/331704/en

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