TARGETED FLUOROMAGNETIC NANOPARTICLES FOR IMAGING OF BREAST CANCER MCF-7 CELLS

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HEIDARI MAJD MOSTAFA; BARAR JALEH; ASGARI DAVOUD; RASHIDI MOHAMMAD REZA; KAFIL VALA; SHAHBAZI JAVID; OMIDI YADOLLAH

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Journal: Advanced Pharmaceutical Bulletin Year:2013 | Volume:3 | Issue:1 Page(s): 189-195

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Title

TARGETED FLUOROMAGNETIC NANOPARTICLES FOR IMAGING OF BREAST CANCER MCF-7 CELLS

Author(s)

Keywords

MAGNETIC NANOPARTICLES

FOLATE RECEPTOR

BREAST CANCER

MCF-7 CELLS

INTERNALIZATION

Abstract

Purpose: To achieve simultaneous imaging and therapy potentials, targeted fluoroMAGNETIC NANOPARTICLES were synthesized and examined in human BREAST CANCER MCF-7 CELLS.Methods: Fe3O4 nanoparticles (NPs) were synthesized through thermal decomposition of Fe (acac) 3. Then, MAGNETIC NANOPARTICLES (MNPs) modified by dopamine-poly ethylene glycol (PEG) -NH2; finally, half equivalent fluorescein isothiocyanate (FITC) and half equivalent folic acid were conjugated to one equivalent of it. The presence of Fe3O4-DPA-PEG-FA/FITC in the FOLATE RECEPTOR (FR) positive MCF-7 CELLS was determined via fluorescent microscopy to monitor the cellular interaction of MNPs.Results: FT-IR spectra of final compound confirmed existence of fluorescein on folic acid grafted MNPs. The Fe3O4-DPA-PEG-FA/FITC NPs, which displayed a size rang about 30-35 nm using scanning electron microscopy (SEM) and transmission electron microscopy (TEM), were able to actively recognize the FR-positive MCF-7 CELLS, but not the FR-negative A549 cells.Conclusion: The uniform nano-sized Fe3O4-DPA-PEG-FA/FITC NPs displayed great potential as theranostics and can be used for targeted imaging of various tumors that overexpress FR.

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APA: Copy

HEIDARI MAJD, MOSTAFA, BARAR, JALEH, ASGARI, DAVOUD, RASHIDI, MOHAMMAD REZA, KAFIL, VALA, SHAHBAZI, JAVID, & OMIDI, YADOLLAH. (2013). TARGETED FLUOROMAGNETIC NANOPARTICLES FOR IMAGING OF BREAST CANCER MCF-7 CELLS. ADVANCED PHARMACEUTICAL BULLETIN, 3(1), 189-195. SID. https://sid.ir/paper/331707/en

Vancouver: Copy

HEIDARI MAJD MOSTAFA, BARAR JALEH, ASGARI DAVOUD, RASHIDI MOHAMMAD REZA, KAFIL VALA, SHAHBAZI JAVID, OMIDI YADOLLAH. TARGETED FLUOROMAGNETIC NANOPARTICLES FOR IMAGING OF BREAST CANCER MCF-7 CELLS. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2013;3(1):189-195. Available from: https://sid.ir/paper/331707/en

IEEE: Copy

MOSTAFA HEIDARI MAJD, JALEH BARAR, DAVOUD ASGARI, MOHAMMAD REZA RASHIDI, VALA KAFIL, JAVID SHAHBAZI, and YADOLLAH OMIDI, “TARGETED FLUOROMAGNETIC NANOPARTICLES FOR IMAGING OF BREAST CANCER MCF-7 CELLS,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 3, no. 1, pp. 189–195, 2013, [Online]. Available: https://sid.ir/paper/331707/en

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