DAMPENING OF SEROTONERGIC SYSTEM THROUGH 5HT1A RECEPTORS IS A PROMISING TARGET FOR TREATMENT OF LEVODOPA INDUCED MOTOR PROBLEMS

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MAHMOUDI JAVAD; FARHOUDI MEHDI; REYHANI RAD SIAMAK; SADIGH ETEGHAD SAEED

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Journal: Advanced Pharmaceutical Bulletin Year:2013 | Volume:3 | Issue:2 Page(s): 439-441

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Title

DAMPENING OF SEROTONERGIC SYSTEM THROUGH 5HT1A RECEPTORS IS A PROMISING TARGET FOR TREATMENT OF LEVODOPA INDUCED MOTOR PROBLEMS

Author(s)

MAHMOUDI JAVAD | FARHOUDI MEHDI | REYHANI RAD SIAMAK | SADIGH ETEGHAD SAEED | Issue Writer Certificate

Keywords

LEVODOPA

5HT1A RECEPTOR

SEROTONERGIC NEURONS

DOPAMINERGIC NEURONS

COMPENSATORY CO-TRANSMISSION

Abstract

During long-term treatment with LEVODOPA, majority of patients with Parkinson's disease experience some abnormal motor problems including of LEVODOPA induced dyskinesia (LID) and wearing off. Incredible evidences suggest that SEROTONERGIC NEURONS compensate some functions of lost DOPAMINERGIC NEURONS in Parkinson's disease especially in advanced disease stages. Therefore, it has been postulated that SEROTONERGIC NEURONS are the major source for development of these unwanted effects.5HT1A receptors are located on the SEROTONERGIC NEURONS and are involved in regulation of normal motor functions. With respect to the role of serotonergic projection in Parkinson's disease and importance of 5HT1A receptors in motor activity it seems that inactivation of these neurons by stimulation of 5HT1A receptors could provide benefits in treatment of LEVODOPA induced motor impairments.

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APA: Copy

MAHMOUDI, JAVAD, FARHOUDI, MEHDI, REYHANI RAD, SIAMAK, & SADIGH ETEGHAD, SAEED. (2013). DAMPENING OF SEROTONERGIC SYSTEM THROUGH 5HT_1A RECEPTORS IS A PROMISING TARGET FOR TREATMENT OF LEVODOPA INDUCED MOTOR PROBLEMS. ADVANCED PHARMACEUTICAL BULLETIN, 3(2), 439-441. SID. https://sid.ir/paper/331787/en

Vancouver: Copy

MAHMOUDI JAVAD, FARHOUDI MEHDI, REYHANI RAD SIAMAK, SADIGH ETEGHAD SAEED. DAMPENING OF SEROTONERGIC SYSTEM THROUGH 5HT_1A RECEPTORS IS A PROMISING TARGET FOR TREATMENT OF LEVODOPA INDUCED MOTOR PROBLEMS. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2013;3(2):439-441. Available from: https://sid.ir/paper/331787/en

IEEE: Copy

JAVAD MAHMOUDI, MEHDI FARHOUDI, SIAMAK REYHANI RAD, and SAEED SADIGH ETEGHAD, “DAMPENING OF SEROTONERGIC SYSTEM THROUGH 5HT_1A RECEPTORS IS A PROMISING TARGET FOR TREATMENT OF LEVODOPA INDUCED MOTOR PROBLEMS,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 3, no. 2, pp. 439–441, 2013, [Online]. Available: https://sid.ir/paper/331787/en

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