ANTI-INFLAMMATORY EFFECTS OF ZINGIBER OFFICINALE IN TYPE 2 DIABETIC PATIENTS

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MAHLUJI SEPIDE; OSTADRAHIMI ALIREZA; MOBASSERI MAJID; EBRAHIMZADE ATTARI VAHIDE; PAYAHOO LALEH

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Journal Paper

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Journal: Advanced Pharmaceutical Bulletin Year:2013 | Volume:3 | Issue:2 Page(s): 273-276

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Title

ANTI-INFLAMMATORY EFFECTS OF ZINGIBER OFFICINALE IN TYPE 2 DIABETIC PATIENTS

Author(s)

Keywords

GINGER

INFLAMMATION

TNF-α

DIABETES

Abstract

Purpose: Low-grade INFLAMMATION, a common feature in type 2 DIABETES (DM2), causes some chronic complications in these patients. The present study was aimed to evaluate the effects of GINGER (Zingiber officinale) on pro-inflammatory cytokines (IL-6 and TNF-a) and the acute phase protein hs-CRP in DM2 patients as a randomized double-blind placebo controlled trial.Methods: A total of 64 DM2 patients randomly were assigned to GINGER or placebo groups and received 2 tablets/day of each for 2 months. The concentrations of IL-6, TNF-a and hs-CRP in blood samples were analyzed before and after the intervention.Results: GINGER supplementation significantly reduced the levels of TNF-a (P=0.006), IL-6 (P=0.02) and hs-CRP (P=0.012) in GINGER group in comparison to baseline. Moreover, the analysis of covariance showed that the group received GINGER supplementation significantly lowered TNF-a (15.3±4.6 vs.19.6±5.2; P=0.005) and hs-CRP (2.42±1.7 vs.2.56±2.18; P=.016) concentrations in comparison to control group. While there were no significant changes in IL-6 (7.9±2.1 vs.7.8±2.9; P>.05).Conclusion: In conclusion, GINGER supplementation in oral administration reduced INFLAMMATION in type 2 diabetic patients. So it may be a good remedy to diminish the risk of some chronic complications of DIABETES.

Cites

THE EFFECT OF GINGER POWDER SUPPLEMENTATION ON LIPID PROFILE IN RHEUMATOID ARTHRITIS PATIENTS

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APA: Copy

MAHLUJI, SEPIDE, OSTADRAHIMI, ALIREZA, MOBASSERI, MAJID, EBRAHIMZADE ATTARI, VAHIDE, & PAYAHOO, LALEH. (2013). ANTI-INFLAMMATORY EFFECTS OF ZINGIBER OFFICINALE IN TYPE 2 DIABETIC PATIENTS. ADVANCED PHARMACEUTICAL BULLETIN, 3(2), 273-276. SID. https://sid.ir/paper/331801/en

Vancouver: Copy

MAHLUJI SEPIDE, OSTADRAHIMI ALIREZA, MOBASSERI MAJID, EBRAHIMZADE ATTARI VAHIDE, PAYAHOO LALEH. ANTI-INFLAMMATORY EFFECTS OF ZINGIBER OFFICINALE IN TYPE 2 DIABETIC PATIENTS. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2013;3(2):273-276. Available from: https://sid.ir/paper/331801/en

IEEE: Copy

SEPIDE MAHLUJI, ALIREZA OSTADRAHIMI, MAJID MOBASSERI, VAHIDE EBRAHIMZADE ATTARI, and LALEH PAYAHOO, “ANTI-INFLAMMATORY EFFECTS OF ZINGIBER OFFICINALE IN TYPE 2 DIABETIC PATIENTS,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 3, no. 2, pp. 273–276, 2013, [Online]. Available: https://sid.ir/paper/331801/en

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