INVESTIGATING THE APOPTOSIS ABILITY OF ETHYLENEDIAMINE 8- HYDROXYQUINOLINATO PALLADIUM (II) COMPLEX (SHORT COMMUNICATION)

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MANSOURI TORSHIZI HASSAN; REZAEI ELHAM; KAMRANFAR FARZANEH; HEIDARI MAJD MOSTAFA

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Journal Paper

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Journal: Advanced Pharmaceutical Bulletin Year:2016 | Volume:6 | Issue:3 Page(s): 449-453

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Title

INVESTIGATING THE APOPTOSIS ABILITY OF ETHYLENEDIAMINE 8- HYDROXYQUINOLINATO PALLADIUM (II) COMPLEX (SHORT COMMUNICATION)

Author(s)

MANSOURI TORSHIZI HASSAN | REZAEI ELHAM | KAMRANFAR FARZANEH | HEIDARI MAJD MOSTAFA | Issue Writer Certificate

Keywords

PALLADIUM COMPLEX

8-HYDROXYQUINOLINE

MCF-7

DU145

TUNEL ASSAY

FLUORESCENT MICROSCOPE

Abstract

Purpose: High solubility, low renal toxicity and apoptosis-inducing ability of PALLADIUM COMPLEXes are the reasons for their synthesis.Methods: In vitro cytotoxic study of previously synthesized [Pd (en) (8HQ)] NO3, was carried out on breast cancer MCF-7 cell lines and prostate cancer DU145 cell lines. DNA fragmentation indicative of apoptotic was also evaluated by TUNEL ASSAY on DU145 cell line.Results: FT-IR spectra of final complex confirmed the existence of chelating ligands. The DU145 cells unlike the MCF-7 cells, demonstrated the significant influence of the Pd (II) complex. The IC50 values of [Pd (en) (8HQ)] NO3 and cisplatin on DU145 cells were 27 and 8.3 mM, respectively. Moreover, nearly 38% apoptosis was evident in DU145 cells after treatment with [Pd (en) (8HQ)] NO3.Conclusion: [Pd (en) (8HQ)] NO3 has great potential in DNA binding and induction of apoptosis; thus it can be used in the future against prostate cancer.

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APA: Copy

MANSOURI TORSHIZI, HASSAN, REZAEI, ELHAM, KAMRANFAR, FARZANEH, & HEIDARI MAJD, MOSTAFA. (2016). INVESTIGATING THE APOPTOSIS ABILITY OF ETHYLENEDIAMINE 8- HYDROXYQUINOLINATO PALLADIUM (II) COMPLEX (SHORT COMMUNICATION). ADVANCED PHARMACEUTICAL BULLETIN, 6(3), 449-453. SID. https://sid.ir/paper/331833/en

Vancouver: Copy

MANSOURI TORSHIZI HASSAN, REZAEI ELHAM, KAMRANFAR FARZANEH, HEIDARI MAJD MOSTAFA. INVESTIGATING THE APOPTOSIS ABILITY OF ETHYLENEDIAMINE 8- HYDROXYQUINOLINATO PALLADIUM (II) COMPLEX (SHORT COMMUNICATION). ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2016;6(3):449-453. Available from: https://sid.ir/paper/331833/en

IEEE: Copy

HASSAN MANSOURI TORSHIZI, ELHAM REZAEI, FARZANEH KAMRANFAR, and MOSTAFA HEIDARI MAJD, “INVESTIGATING THE APOPTOSIS ABILITY OF ETHYLENEDIAMINE 8- HYDROXYQUINOLINATO PALLADIUM (II) COMPLEX (SHORT COMMUNICATION),” ADVANCED PHARMACEUTICAL BULLETIN, vol. 6, no. 3, pp. 449–453, 2016, [Online]. Available: https://sid.ir/paper/331833/en

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