SODIUM ALGINATE WITH PEG/PEO BLENDS AS A FLOATING DRUG DELIVERY CARRIER – IN VITRO EVALUATION

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MARY CHRISTE SONIA; SWAMIAPPAN SASIKUMAR

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Journal: Advanced Pharmaceutical Bulletin Year:2016 | Volume:6 | Issue:3 Page(s): 435-442

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Information Journal Paper

Title

SODIUM ALGINATE WITH PEG/PEO BLENDS AS A FLOATING DRUG DELIVERY CARRIER – IN VITRO EVALUATION

Author(s)

MARY CHRISTE SONIA | SWAMIAPPAN SASIKUMAR | Issue Writer Certificate

Keywords

CIPROFLOXACIN HYDROCHLORIDE

FLOATING DRUG DELIVERY SYSTEM

POLYETHYLENE GLYCOL

POLYETHYLENE OXIDE

SODIUM ALGINATE

SODIUM BICARBONATE

Abstract

Purpose: FLOATING DRUG DELIVERY SYSTEM reduces the quantity of drug intake and the risk of overloading the organs with excess drug.Methods: In the present study, we prepared the blends of SODIUM ALGINATE with POLYETHYLENE GLYCOL (PEG) and POLYETHYLENE OXIDE (PEO) as a matrix, sodium hydrogen carbonate as a pore forming agent, methyl cellulose as a binder and barium chloride containing 10% acetic acid as a hardening agent. Different ratios of pore forming agent to the polymer blend was used to prepare the floating beads with different porosity and morphology. CIPROFLOXACIN HYDROCHLORIDE was used as a model drug for the release kinetics studies.Results: The beads were characterized by optical and FESEM microscopy to study the morphology and pore dimensions. The results obtained shows decrease in beads size with increase in the concentration of the pore forming agent. The swelling properties of the beads were found to be in the range of 80% to 125%. The release kinetics of the ciprofloxacin from the beads was measured by UV-Visible spectroscopy at lmax of 278nm and the results shows for highly porous beads.Conclusion: By varying the amount of alginate and pore forming agent the release kinetics is found to get altered. As a result, CIPROFLOXACIN HYDROCHLORIDE release is found to be sustained from the blended beads.

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APA: Copy

MARY, CHRISTE SONIA, & SWAMIAPPAN, SASIKUMAR. (2016). SODIUM ALGINATE WITH PEG/PEO BLENDS AS A FLOATING DRUG DELIVERY CARRIER – IN VITRO EVALUATION. ADVANCED PHARMACEUTICAL BULLETIN, 6(3), 435-442. SID. https://sid.ir/paper/331836/en

Vancouver: Copy

MARY CHRISTE SONIA, SWAMIAPPAN SASIKUMAR. SODIUM ALGINATE WITH PEG/PEO BLENDS AS A FLOATING DRUG DELIVERY CARRIER – IN VITRO EVALUATION. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2016;6(3):435-442. Available from: https://sid.ir/paper/331836/en

IEEE: Copy

CHRISTE SONIA MARY, and SASIKUMAR SWAMIAPPAN, “SODIUM ALGINATE WITH PEG/PEO BLENDS AS A FLOATING DRUG DELIVERY CARRIER – IN VITRO EVALUATION,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 6, no. 3, pp. 435–442, 2016, [Online]. Available: https://sid.ir/paper/331836/en

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