مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ACUTE AND SUBCHRONIC TOXICITY STUDY OF THE MEDIAN SEPTUM OF JUGLANS REGIA IN WISTAR RATS

Pages

  541-549

Abstract

 Purpose: Median septum of JUGLANS REGIA L. (Juglandaceae) with anti-diabetic effects has been used in Iranian traditional medicine. The present study estimates both oral acute and subchronic toxicities.Methods: In the oral acute TOXICITY study, female WISTAR RATS were treated with doses of 10, 100, 1000, 1600, 2900 and 5000 mg/ kg of the JUGLANS REGIA septum of methanol extract (JRSME), and were monitored for 14 days. In subchronic study, JRSME was administered by gavage at dose of 1000 mg/kg daily in WISTAR RATS for 28 days. Antioxidant status and biochemical examinations were fulfilled, and the vital organs were subjected to pathological analyses.Results: The extract did not produce any toxic signs or deaths; the medium lethal dose must be higher than 5000 mg/kg. In subchronic study, No significant morphological and histopathological changes were observed in the studied tissues. There was a significant increase in serum malondialdehyde (MDA) level in treated group compared to control after 4 weeks of JRSME intake. The treatment of rats resulted in a significant reduction of serum urea level (p<0.05), kidney’s xanthine dehydrogenase (XDH) activity (p<0.001) and elevation of aldehyde oxidase (AO) activity (p<0.05) in kidney. In the treated group, the mean diameter of glomerulus and proximal urine tube epithelium stature was slightly greater than control group. A significant increase in serum MDA level is subject for further studies.Conclusion: This study showed that the extract has no acute or subacute adverse effects with dose of 1000 mg/kg. The administration of JRSME may improve kidney structure and function and help in treatment of some chronic diseases.

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    APA: Copy

    RAVANBAKHSH, ASMA, MAHDAVI, MAJID, JALILZADE AMIN, GHADER, JAVADI, SHAHRAM, MAHAM, MASOUD, MOHAMMADNEJAD, DARYOSH, & RASHIDI, MOHAMMAD REZA. (2016). ACUTE AND SUBCHRONIC TOXICITY STUDY OF THE MEDIAN SEPTUM OF JUGLANS REGIA IN WISTAR RATS. ADVANCED PHARMACEUTICAL BULLETIN, 6(4), 541-549. SID. https://sid.ir/paper/331841/en

    Vancouver: Copy

    RAVANBAKHSH ASMA, MAHDAVI MAJID, JALILZADE AMIN GHADER, JAVADI SHAHRAM, MAHAM MASOUD, MOHAMMADNEJAD DARYOSH, RASHIDI MOHAMMAD REZA. ACUTE AND SUBCHRONIC TOXICITY STUDY OF THE MEDIAN SEPTUM OF JUGLANS REGIA IN WISTAR RATS. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2016;6(4):541-549. Available from: https://sid.ir/paper/331841/en

    IEEE: Copy

    ASMA RAVANBAKHSH, MAJID MAHDAVI, GHADER JALILZADE AMIN, SHAHRAM JAVADI, MASOUD MAHAM, DARYOSH MOHAMMADNEJAD, and MOHAMMAD REZA RASHIDI, “ACUTE AND SUBCHRONIC TOXICITY STUDY OF THE MEDIAN SEPTUM OF JUGLANS REGIA IN WISTAR RATS,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 6, no. 4, pp. 541–549, 2016, [Online]. Available: https://sid.ir/paper/331841/en

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