CONCURRENT INFLAMMATION AUGMENTS ANTIMALARIAL DRUGS-INDUCED LIVER INJURY IN RATS

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NIKNAHAD HOSSEIN; HEIDARI REZA; FIRUZI ROYA; ABAZARI FARZANEH; RAMEZANI MARAL; AZARPIRA NEGAR; HOSSEINZADEH MASSOOD; NAJIBI ASMA; SAEEDI ARASTOO

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Journal: Advanced Pharmaceutical Bulletin Year:2016 | Volume:6 | Issue:4 Page(s): 617-625

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Title

CONCURRENT INFLAMMATION AUGMENTS ANTIMALARIAL DRUGS-INDUCED LIVER INJURY IN RATS

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Keywords

DRUG-INDUCED LIVER INJURY

HEPATOTOXICITY

INFLAMMATION

LIPOPOLYSACCHARIDE

MALARIA

Abstract

Purpose: Accumulating evidence suggests that drug exposure during a modest INFLAMMATION induced by bacterial LIPOPOLYSACCHARIDE (LPS) might increase the risk of DRUG-INDUCED LIVER INJURY. The current investigation was designed to test if antimalarial drugs HEPATOTOXICITY is augmented in LPS-treated animals.Methods: Rats were pre-treated with LPS (100 mg/kg, i.p). Afterward, non-hepatotoxic doses of amodiaquine (25, 50 and 100 mg/kg, oral) and chloroquine (25, 50 and 100 mg/kg, oral) were administered.Results: Interestingly, liver injury was evident only in animals treated with both drug and LPS as estimated by pathological changes in serum biochemistry (ALT, AST, LDH, and TNF-a), and liver tissue (severe hepatitis, endotheliitis, and sinusoidal congestion). An increase in liver myeloperoxidase enzyme activity, lipid peroxidation, and protein carbonylation, along with tissue glutathione depletion were also detected in LPS and drug co-treated animals.Conclusion: Antimalarial drugs rendered hepatotoxic in animals undergoing a modest INFLAMMATION. These results indicate a synergistic liver injury from co-exposure to antimalarial drugs and INFLAMMATION.

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APA: Copy

NIKNAHAD, HOSSEIN, HEIDARI, REZA, FIRUZI, ROYA, ABAZARI, FARZANEH, RAMEZANI, MARAL, AZARPIRA, NEGAR, HOSSEINZADEH, MASSOOD, NAJIBI, ASMA, & SAEEDI, ARASTOO. (2016). CONCURRENT INFLAMMATION AUGMENTS ANTIMALARIAL DRUGS-INDUCED LIVER INJURY IN RATS. ADVANCED PHARMACEUTICAL BULLETIN, 6(4), 617-625. SID. https://sid.ir/paper/331844/en

Vancouver: Copy

NIKNAHAD HOSSEIN, HEIDARI REZA, FIRUZI ROYA, ABAZARI FARZANEH, RAMEZANI MARAL, AZARPIRA NEGAR, HOSSEINZADEH MASSOOD, NAJIBI ASMA, SAEEDI ARASTOO. CONCURRENT INFLAMMATION AUGMENTS ANTIMALARIAL DRUGS-INDUCED LIVER INJURY IN RATS. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2016;6(4):617-625. Available from: https://sid.ir/paper/331844/en

IEEE: Copy

HOSSEIN NIKNAHAD, REZA HEIDARI, ROYA FIRUZI, FARZANEH ABAZARI, MARAL RAMEZANI, NEGAR AZARPIRA, MASSOOD HOSSEINZADEH, ASMA NAJIBI, and ARASTOO SAEEDI, “CONCURRENT INFLAMMATION AUGMENTS ANTIMALARIAL DRUGS-INDUCED LIVER INJURY IN RATS,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 6, no. 4, pp. 617–625, 2016, [Online]. Available: https://sid.ir/paper/331844/en

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