مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

344
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

134
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

EVALUATION OF MIR-141, MIR-200C, MIR-30B EXPRESSION AND CLINICOPATHOLOGICAL FEATURES OF BLADDER CANCER

Pages

  32-39

Abstract

 Bladder cancer (BC) ranks the second most common genitourinary tract malignant tumor with high mortality and 70% recurrence rate worldwide. MiRNAs expression has noticeable role in bladder tumorigenesis. The purpose of this study was to assess miR-200c, miR-30b and miR-141 in tissue samples of patients with BC and healthy adjacent tissue samples and their association with muscle invasion, grade and the size of the tumor. Transurethral resection tissue samples were collected from thirty- five newly diagnosed untreated patients with BC from 2013 to 2014. The control group consisted of adjacent normal urothelium. All samples, observed by two pathologists, were diagnosed transitional cell carcinomas (TCC) with the proportion of tumor cells greater than 80%. Total RNA including miRNAs was extracted from about 50 mg tissue samples by applying TRIzol reagent.2 (-DD CT) method was used to calculate relative quantification of miRNA expression. Two of 35 patients were females and the other 33 were males. Invasion to bladder muscle was observed in 13 (37%) cases. MiR-141, miR-200-c and miR30-b were up-regulated in 91%, 79% and 64% of malignant tissues, respectively. Down-regulation of miR- 141 had a strong association with muscle invasion (P=0.017). Significant inverse correlation between grading and miRNA-141 level was observed (P=0.043).

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    MAHDAVINEZHAD, ALI, MOUSAVI BAHAR, SEYED HABIBOLLAH, POOROLAJAL, JALAL, YADEGARAZARI, REZA, JAFARI, MOHAMMAD, SHABAB, NOOSHIN, & SAIDIJAM, MASSOUD. (2015). EVALUATION OF MIR-141, MIR-200C, MIR-30B EXPRESSION AND CLINICOPATHOLOGICAL FEATURES OF BLADDER CANCER. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 4(1), 32-39. SID. https://sid.ir/paper/332154/en

    Vancouver: Copy

    MAHDAVINEZHAD ALI, MOUSAVI BAHAR SEYED HABIBOLLAH, POOROLAJAL JALAL, YADEGARAZARI REZA, JAFARI MOHAMMAD, SHABAB NOOSHIN, SAIDIJAM MASSOUD. EVALUATION OF MIR-141, MIR-200C, MIR-30B EXPRESSION AND CLINICOPATHOLOGICAL FEATURES OF BLADDER CANCER. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2015;4(1):32-39. Available from: https://sid.ir/paper/332154/en

    IEEE: Copy

    ALI MAHDAVINEZHAD, SEYED HABIBOLLAH MOUSAVI BAHAR, JALAL POOROLAJAL, REZA YADEGARAZARI, MOHAMMAD JAFARI, NOOSHIN SHABAB, and MASSOUD SAIDIJAM, “EVALUATION OF MIR-141, MIR-200C, MIR-30B EXPRESSION AND CLINICOPATHOLOGICAL FEATURES OF BLADDER CANCER,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 4, no. 1, pp. 32–39, 2015, [Online]. Available: https://sid.ir/paper/332154/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button