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Information Journal Paper

Title

MULTIPLE INHERITED THROMBOPHILIC GENE POLYMORPHISMS IN SPONTANEOUS ABORTIONS IN TURKISH POPULATION

Pages

  120-127

Abstract

 The aim of this study was to investigate the possible role of multiple inherited thrombophilic gene variations in women with unexplained SPONTANEOUS ABORTIONs. For this purpose, the Factor V Leiden (FVL) (rs6025), Prothrombin G20210A (rs1799963), MTHFR C677T (rs1801133), PAI-1 4G/5G (rs1799889), ACE I/D (rs1799752), eNOS E298D (rs1799983), and Apo E E2/E3/E4 (rs429358) POLYMORPHISMs were genotyped and correlated in spontaneously aborted fetal materials, their mothers and fertile women. Twenty three abortion materials, 22 women with³1 unexplained fetal loss, and 22 control subjects with at least two healthy term infants as a control group were studied. Target SNPs for each gene were analyzed by real time-PCR technique after genomic DNA isolation from maternal blood-EDTA, control group blood-EDTA and spontaneously aborted fetal tissues. Some cases had a single thrombophilic POLYMORPHISM, but the rest of the patients and fetal materials had combined thrombophilic POLYMORPHISMs. The PAI-1 4G/5G+4G/4G (P=0.0017), 4G/4G (P=0.0253), eNOS 894GT+894TT (P=0.0011) genotypes and T allele (P=0.0185), Apo E E3/E4+E3/E2+E2/E4 (P<0.0001) genotypes, E2 (P<0.0001) and E4 (P<0.0001) alleles were higher in spontaneously aborted fetal materials when compared to their mothers and control group. The Factor V Leiden rs6025, Prothrombin G20210A, MTHFR C677T, ACE I/D genotypes were different for each group but not statistically significant due to relatively small size of the samples (P>0.05). Our results indicated that combined thrombophilic gene variations may be associated with increased risk for SPONTANEOUS ABORTIONs and results need to be confirmed by larger sample size.

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    APA: Copy

    YALCINTEPE, SINEM, OZDEMIR, OZTURK, HACIVELIOGLU, SERVET OZDEN, AKURUT, CISEM, KOC, EVRIM, ULUDAG, AHMET, COSAR, EMINE, & SILAN, FATMA. (2015). MULTIPLE INHERITED THROMBOPHILIC GENE POLYMORPHISMS IN SPONTANEOUS ABORTIONS IN TURKISH POPULATION. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 4(2), 120-127. SID. https://sid.ir/paper/332156/en

    Vancouver: Copy

    YALCINTEPE SINEM, OZDEMIR OZTURK, HACIVELIOGLU SERVET OZDEN, AKURUT CISEM, KOC EVRIM, ULUDAG AHMET, COSAR EMINE, SILAN FATMA. MULTIPLE INHERITED THROMBOPHILIC GENE POLYMORPHISMS IN SPONTANEOUS ABORTIONS IN TURKISH POPULATION. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2015;4(2):120-127. Available from: https://sid.ir/paper/332156/en

    IEEE: Copy

    SINEM YALCINTEPE, OZTURK OZDEMIR, SERVET OZDEN HACIVELIOGLU, CISEM AKURUT, EVRIM KOC, AHMET ULUDAG, EMINE COSAR, and FATMA SILAN, “MULTIPLE INHERITED THROMBOPHILIC GENE POLYMORPHISMS IN SPONTANEOUS ABORTIONS IN TURKISH POPULATION,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 4, no. 2, pp. 120–127, 2015, [Online]. Available: https://sid.ir/paper/332156/en

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