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Information Journal Paper

Title

P38 MAPK AND PI3K/AKT SIGNALLING CASCADES IN PARKINSON’S DISEASE (REVIEW ARTICLE)

Pages

  67-86

Keywords

PARKINSON’S DISEASE (PD) 
OXIDATIVE STRESS (OS) 

Abstract

 Parkinson's disease (PD) is a chronic neurodegenerative condition which has the second largest incidence rate among all other neurodegenerative disorders barring Alzheimer's disease (AD). Currently there is no cure and researchers continue to probe the therapeutic prospect in cell cultures and animal models of PD. Out of the several factors contributing to PD prognosis, the role of p38 MAPK (Mitogen activated protein-kinase) and PI3K/AKT signalling module in PD brains is crucial because the impaired balance between the pro- apoptotic and anti-apoptotic pathways trigger unwanted phenotypes such as microglia activation, NEUROINFLAMMATION, oxidative stress and APOPTOSIS. These factors continue challenging the brain homeostasis in initial stages thereby essentially assisting the dopaminergic (DA) neurons towards progressive degeneration in PD. NEUROTHERAPEUTICS against PD shall then be targeted against the misregulated accomplices of the p38 and PI3K/AKT cascades. In this review, we have outlined many such established mechanisms involving the p38 MAPK and PI3K/AKT pathways which can offer therapeutic windows for the rectification of aberrant DA neuronal dynamics in PD brains.

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    Cite

    APA: Copy

    KUMAR JHA, SAURABH, KUMAR JHA, NIRAJ, KAR, ROHAN, AMBASTA, RASHMI K., & KUMAR, PRAVIR. (2015). P38 MAPK AND PI3K/AKT SIGNALLING CASCADES IN PARKINSON’S DISEASE (REVIEW ARTICLE). INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 4(2), 67-86. SID. https://sid.ir/paper/332158/en

    Vancouver: Copy

    KUMAR JHA SAURABH, KUMAR JHA NIRAJ, KAR ROHAN, AMBASTA RASHMI K., KUMAR PRAVIR. P38 MAPK AND PI3K/AKT SIGNALLING CASCADES IN PARKINSON’S DISEASE (REVIEW ARTICLE). INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2015;4(2):67-86. Available from: https://sid.ir/paper/332158/en

    IEEE: Copy

    SAURABH KUMAR JHA, NIRAJ KUMAR JHA, ROHAN KAR, RASHMI K. AMBASTA, and PRAVIR KUMAR, “P38 MAPK AND PI3K/AKT SIGNALLING CASCADES IN PARKINSON’S DISEASE (REVIEW ARTICLE),” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 4, no. 2, pp. 67–86, 2015, [Online]. Available: https://sid.ir/paper/332158/en

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