APOBEC3 DELETION IS ASSOCIATED WITH BREAST CANCER RISK IN A SAMPLE OF SOUTHEAST IRANIAN POPULATION

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REZAEI MARYAM; HASHEMI MOHAMMAD; HASHEMI SEYED MEHDI; MASHHADI MOHAMMAD ALI; TAHERI MOHSEN

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Journal: International Journal of Molecular and Cellular Medicine Year:2015 | Volume:4 | Issue:2 Page(s): 103-108

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Title

APOBEC3 DELETION IS ASSOCIATED WITH BREAST CANCER RISK IN A SAMPLE OF SOUTHEAST IRANIAN POPULATION

Author(s)

Keywords

APOBEC3

BREAST CANCER

POLYMORPHISM

DELETION

Abstract

Breast Cancer (BC) is considered as one of the most important causes of death worldwide. Previous studies showed that apolipoprotein B mRNA- editing catalytic polypeptide-like 3 (APOBEC3) gene DELETION significantly increased the risk of BC risk in Chinese and European women. The present study aimed to assess the possible impact of APOBEC3 DELETION and the risk of BC in a sample of Iranian population. The APOBEC3 insertion/deletion (I/D) was analyzed in a case- control study including 262 BC patients and 217 healthy women. Polymerase chain reaction (PCR) was used to genotype the variant in APOBEC3 gene. The findings of this study showed that I/D as well as I/D+D/D genotype increased the risk of BC (OR=1.57, 95% CI=1.07- 2.31, p=0.025 and OR=1.50, 95% CI=1.03- 2.19, p=0.037, respectively) in comparison with I/I genotype. In conclusion, our findings suggest that APOBEC3 DELETION POLYMORPHISM increased the risk of BC in an Iranian population in the southeast of Iran.

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APA: Copy

REZAEI, MARYAM, HASHEMI, MOHAMMAD, HASHEMI, SEYED MEHDI, MASHHADI, MOHAMMAD ALI, & TAHERI, MOHSEN. (2015). APOBEC3 DELETION IS ASSOCIATED WITH BREAST CANCER RISK IN A SAMPLE OF SOUTHEAST IRANIAN POPULATION. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 4(2), 103-108. SID. https://sid.ir/paper/332161/en

Vancouver: Copy

REZAEI MARYAM, HASHEMI MOHAMMAD, HASHEMI SEYED MEHDI, MASHHADI MOHAMMAD ALI, TAHERI MOHSEN. APOBEC3 DELETION IS ASSOCIATED WITH BREAST CANCER RISK IN A SAMPLE OF SOUTHEAST IRANIAN POPULATION. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2015;4(2):103-108. Available from: https://sid.ir/paper/332161/en

IEEE: Copy

MARYAM REZAEI, MOHAMMAD HASHEMI, SEYED MEHDI HASHEMI, MOHAMMAD ALI MASHHADI, and MOHSEN TAHERI, “APOBEC3 DELETION IS ASSOCIATED WITH BREAST CANCER RISK IN A SAMPLE OF SOUTHEAST IRANIAN POPULATION,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 4, no. 2, pp. 103–108, 2015, [Online]. Available: https://sid.ir/paper/332161/en

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