ASSOCIATION OF CPG-SNP AND 3'UTR-SNP OF WFS1 WITH THE RISK OF TYPE 2 DIABETES MELLITUS IN AN IRANIAN POPULATION

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TORKAMANDI SHAHRAM; BASTAMI MILAD; GHAEDI HAMID; TARIGHI SHAHRIAR; SHOKRI FAZLOLLAH; JAVADI ABDOLREZA; MIRFAKHRAIE REZA; OMRANI MIR DAVOOD

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Journal: International Journal of Molecular and Cellular Medicine Year:2017 | Volume:6 | Issue:4 Page(s): 197-203

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Title

ASSOCIATION OF CPG-SNP AND 3'UTR-SNP OF WFS1 WITH THE RISK OF TYPE 2 DIABETES MELLITUS IN AN IRANIAN POPULATION

Author(s)

Keywords

WFS-1

TYPE 2 DIABETES

GENOME WIDE ASSOCIATION STUDY

SINGLE NUCLEOTIDE POLYMORPHISMS

Abstract

Type 2 diabetes mellitus (T2DM)is one of the most common multifactorial disorders in Iran. Recent genome wide association studies (GWASs) and functional studies have suggested thatWFS1 may predispose individuals to T2DM. However, to date, the possible association of such variants with T2DM in Iranians remained unknown.Here, we investigated the association of the two polymorphisms ofWFS1 (rs1801214 a CpG-SNP, and rs1046320 a 3’UTR-SNP) with T2DM in an Iranian population. The study population comprised 432 unrelated Iranian individuals including 220 patients with T2DM, and 211 unrelated healthy control subjects. Genotyping was performed using PCR-RFLP, and confirmed with sequencing. In a logistic regression analysis, the rs1801214-T allele was associated with a significantly lower risk of T2DM assuming the log-additive model (OR: 0.68, 95% CI: 0.52-0.91, P=0.007539). Moreover, the G allele of rs1046320 was associated with a lower risk of T2DM assuming the log-additive model (OR: 0.68, 95% CI: 0.50- 0.91, P=0.008313). Haplotype analysis revealed that haplotypes that carry at least one protective allele are associated with a lower risk of T2DM. This is a first evidence for the association ofWFS1 rs1801214, and rs1046320 with T2DM in an Iranian population.

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APA: Copy

TORKAMANDI, SHAHRAM, BASTAMI, MILAD, GHAEDI, HAMID, TARIGHI, SHAHRIAR, SHOKRI, FAZLOLLAH, JAVADI, ABDOLREZA, MIRFAKHRAIE, REZA, & OMRANI, MIR DAVOOD. (2017). ASSOCIATION OF CPG-SNP AND 3'UTR-SNP OF WFS1 WITH THE RISK OF TYPE 2 DIABETES MELLITUS IN AN IRANIAN POPULATION. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 6(4), 197-203. SID. https://sid.ir/paper/332172/en

Vancouver: Copy

TORKAMANDI SHAHRAM, BASTAMI MILAD, GHAEDI HAMID, TARIGHI SHAHRIAR, SHOKRI FAZLOLLAH, JAVADI ABDOLREZA, MIRFAKHRAIE REZA, OMRANI MIR DAVOOD. ASSOCIATION OF CPG-SNP AND 3'UTR-SNP OF WFS1 WITH THE RISK OF TYPE 2 DIABETES MELLITUS IN AN IRANIAN POPULATION. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2017;6(4):197-203. Available from: https://sid.ir/paper/332172/en

IEEE: Copy

SHAHRAM TORKAMANDI, MILAD BASTAMI, HAMID GHAEDI, SHAHRIAR TARIGHI, FAZLOLLAH SHOKRI, ABDOLREZA JAVADI, REZA MIRFAKHRAIE, and MIR DAVOOD OMRANI, “ASSOCIATION OF CPG-SNP AND 3'UTR-SNP OF WFS1 WITH THE RISK OF TYPE 2 DIABETES MELLITUS IN AN IRANIAN POPULATION,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 6, no. 4, pp. 197–203, 2017, [Online]. Available: https://sid.ir/paper/332172/en

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