Thymolipoma-associated Myasthenia Gravis with High Titer of Anti-MuSKAb: A Case Report

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POURSADEGHFARD MARYAM; ABOLHASANI FOROUGHI AMIN; KARAMIMAGHAM SINA

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Journal Paper

Paper Information

Journal: International Journal of Molecular and Cellular Medicine Year:2019 | Volume:8 | Issue:1 Page(s): 90-93

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Title

Thymolipoma-associated Myasthenia Gravis with High Titer of Anti-MuSKAb: A Case Report

Author(s)

POURSADEGHFARD MARYAM | ABOLHASANI FOROUGHI AMIN | KARAMIMAGHAM SINA | Issue Writer Certificate

Keywords

Myasthenia gravis

thymolipoma

anti-acetylcholine receptor antibody

anti-Muscle Specific Tyrosine Kinase-Antibody

Abstract

Myasthenia gravis (MG) is a neuromuscular junction disorder caused by pathogenic autoantibodies to some parts of the post-synaptic muscle endplates. About 85% of generalized MG patients have autoantibodies against postsynaptic acetyl-choline receptors (AChR). From the 10-15% of the remaining patients, 45-50% are positive for Muscle Specific Tyrosine Kinase-Antibody (MuSK-Ab). It is believed that the thymus has a critical role in the pathogenesis of the disease with AChR-Ab, specially in patients with thymic abnormalities. In contrast, the role of thymus gland in MG with anti-MuSK-Ab is not clearly obvious. Patients with this antibody virtually have normal or only minimal follicular hyperplastic thymus. The presence of anti-MuSK Ab in a thymolipomatous (an uncommon tumor of thymus) MG is an atypical and new finding of MG because of not only thymolipoma but the presence of anti-MuSK antibodies which makes this case different from the previous reports of the antibodies-associated MG. Here, we present a young woman with thymolipoma and MG (a very uncommon kind of tumor-associated MG) and high level of anti-MuSK-Ab.

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APA: Copy

POURSADEGHFARD, MARYAM, ABOLHASANI FOROUGHI, AMIN, & KARAMIMAGHAM, SINA. (2019). Thymolipoma-associated Myasthenia Gravis with High Titer of Anti-MuSKAb: A Case Report. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 8(1), 90-93. SID. https://sid.ir/paper/332250/en

Vancouver: Copy

POURSADEGHFARD MARYAM, ABOLHASANI FOROUGHI AMIN, KARAMIMAGHAM SINA. Thymolipoma-associated Myasthenia Gravis with High Titer of Anti-MuSKAb: A Case Report. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2019;8(1):90-93. Available from: https://sid.ir/paper/332250/en

IEEE: Copy

MARYAM POURSADEGHFARD, AMIN ABOLHASANI FOROUGHI, and SINA KARAMIMAGHAM, “Thymolipoma-associated Myasthenia Gravis with High Titer of Anti-MuSKAb: A Case Report,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 8, no. 1, pp. 90–93, 2019, [Online]. Available: https://sid.ir/paper/332250/en

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