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Information Journal Paper

Title

Protective Effect of Naringin on Bisphenol A-Induced Cognitive Dysfunction and Oxidative Damage in Rats

Pages

  141-153

Abstract

 Bisphenol A (BPA) is one of the highest volume chemicals produced worldwide, which is used in many plastic industries. The present study aimed to evaluate the effect of BPA on cognitive functions and oxidative stress, and determine whether the naringin (NG) co-administration can modify the effect of this compound on cognitive functions and inhibit any possible oxidative stress in the brain tissue of rats. Adult male Wistar rats were divided into six groups. Group I: control, Group II: BPA-treated rats (50 mg/kg/day), Group III, IV, V: BPA+NG (40, 80, 160 mg/kg/day), Group VI: NG (160 mg/kg/day) alone. Cognitive functions were evaluated using step-down latency (SDL) on a passive avoidance apparatus, and transfer latency (TL) in elevated plus-maze. A significant decrease in SDL, prolongation of TL, noticeable oxidative impairment and increase in acetylcholinesterase activity were observed in the BPA-treated in comparison with the control group. Also, the co-administration of NG (160 mg/kg) antagonized the effect of BPA on SDL and TL, attenuated oxidative damage by lowering malondialdehyde and nitrite concentrations and restored superoxide dismutase, catalase, and glutathione S-transferase activities. On the other hand, acetylcholinesterase activity was reduced in the groups co-administred with NG (80 or 160 mg/kg) and BPA in comparison with the BPA alone-treated group. The present study highlighted the therapeutic potential of NG against BPA-induced cognitive impairment and oxidative damage.

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    APA: Copy

    MAHDAVINIA, MASOUD, AHANGARPOUR, AKRAM, Zeidooni, Leila, SAMIMI, AZIN, Alizadeh, Saeid, DEHGHANI, MOHAMMAD AMIN, & ALBOGHOBEISH, SOHEILA. (2019). Protective Effect of Naringin on Bisphenol A-Induced Cognitive Dysfunction and Oxidative Damage in Rats. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 8(2), 141-153. SID. https://sid.ir/paper/332252/en

    Vancouver: Copy

    MAHDAVINIA MASOUD, AHANGARPOUR AKRAM, Zeidooni Leila, SAMIMI AZIN, Alizadeh Saeid, DEHGHANI MOHAMMAD AMIN, ALBOGHOBEISH SOHEILA. Protective Effect of Naringin on Bisphenol A-Induced Cognitive Dysfunction and Oxidative Damage in Rats. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2019;8(2):141-153. Available from: https://sid.ir/paper/332252/en

    IEEE: Copy

    MASOUD MAHDAVINIA, AKRAM AHANGARPOUR, Leila Zeidooni, AZIN SAMIMI, Saeid Alizadeh, MOHAMMAD AMIN DEHGHANI, and SOHEILA ALBOGHOBEISH, “Protective Effect of Naringin on Bisphenol A-Induced Cognitive Dysfunction and Oxidative Damage in Rats,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 8, no. 2, pp. 141–153, 2019, [Online]. Available: https://sid.ir/paper/332252/en

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