مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

The Role of ERRFI1+808T/G Polymorphism in Diabetic Nephropathy

Pages

  49-55

Abstract

 Nephropathy is a common diabetes complication. ERRFI1 gene which participates in various cellular pathways has been proposed as a candidate gene in diabetic nephropathy. This study aimed to investigate the role of +808T/G polymorphism (rs377349) in ERRFI1 gene in diabetic nephropathy. In this case-control study, patients including diabetes with nephropathy (DN=104), type 2 diabetes without nephropathy (DM=100), and healthy controls (HC=106) were included. DNA was extracted from blood, and genotyping of the +808T/G polymorphism was carried out using PCR-RFLP technique. The differences for genotype and allele frequencies for +808T/G polymorphism in ERRFI1 gene between DN vs. HC and DN+DM vs. HC were significant (P<0. 05) while no significant difference between DN and DM was observed. The allele frequencies were significantly different in DN vs. HC and DN+DM vs. HC in males but not in females. G allele of +808T/G polymorphism in ERRFI1 gene has no significant role in development and progression of diabetic nephropathy in diabetes patients while it is a risk allele for developing diabetes in Iranian population.

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    • Cite

    APA: Copy

    ASGARBEIK, SAEEDEH, MOHAMMAD AMOLI, MAHSA, Enayati, Samaneh, BANDARIAN, FATEMEH, NASLI ESFAHANI, ENSIEH, Forouzanfar, Katayoon, RAZI, FARIDEH, & ANGAJI, SEYED ABDOLHAMID. (2019). The Role of ERRFI1+808T/G Polymorphism in Diabetic Nephropathy. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 8(supp), 49-55. SID. https://sid.ir/paper/332262/en

    Vancouver: Copy

    ASGARBEIK SAEEDEH, MOHAMMAD AMOLI MAHSA, Enayati Samaneh, BANDARIAN FATEMEH, NASLI ESFAHANI ENSIEH, Forouzanfar Katayoon, RAZI FARIDEH, ANGAJI SEYED ABDOLHAMID. The Role of ERRFI1+808T/G Polymorphism in Diabetic Nephropathy. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2019;8(supp):49-55. Available from: https://sid.ir/paper/332262/en

    IEEE: Copy

    SAEEDEH ASGARBEIK, MAHSA MOHAMMAD AMOLI, Samaneh Enayati, FATEMEH BANDARIAN, ENSIEH NASLI ESFAHANI, Katayoon Forouzanfar, FARIDEH RAZI, and SEYED ABDOLHAMID ANGAJI, “The Role of ERRFI1+808T/G Polymorphism in Diabetic Nephropathy,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 8, no. supp, pp. 49–55, 2019, [Online]. Available: https://sid.ir/paper/332262/en

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