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Information Journal Paper

Title

Metabolomics and Cell Therapy in Diabetes Mellitus

Pages

  41-48

Abstract

 Diabetes with a broad spectrum of complications has become a global epidemic metabolic disorder. Till now, several pharmaceutical and non-pharmaceutical therapeutic approaches were applied for its treatment. Cell-based therapies have become promising methods for diabetes treatment. Better understanding of diabetes pathogenesis and identification of its specific biomarkers along with evaluation of different treatments efficacy, can be possible by clarification of specific metabolic modifications during the diabetes progression. Subsequently, metabolomics technology can support this goal as an effective tool. The present review tried to show how metabolomics quantifications can be useful for diabetic monitoring before and after cell therapy. Cell therapy is an alternative approach to achieve diabetes treatments goals including insulin resistance amelioration, insulin independence reparation, and control of glycemia. OMICs approaches provide a comprehensive insight into the molecular mechanisms of cells features and functional mechanism of their genomics, transcriptomics, proteomics, and metabolomics profile which can be useful for their therapeutic application. As a modern technology for the detection and analysis of metabolites in biological samples, metabolomica can identify many of the metabolic and molecular pathways associated with diabetes and its following complications.

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    • Cite

    APA: Copy

    LARIJANI, BAGHER, GOODARZI, PARISA, PAYAB, MOLOUD, Alavi Moghadam, Sepideh, RAHIM, FAKHER, BANA, NIKOO, ABEDI, MINA, Arabi, Maryam, Adibi, Hossein, & GILANY, KAMBIZ. (2019). Metabolomics and Cell Therapy in Diabetes Mellitus. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 8(supp), 41-48. SID. https://sid.ir/paper/332264/en

    Vancouver: Copy

    LARIJANI BAGHER, GOODARZI PARISA, PAYAB MOLOUD, Alavi Moghadam Sepideh, RAHIM FAKHER, BANA NIKOO, ABEDI MINA, Arabi Maryam, Adibi Hossein, GILANY KAMBIZ. Metabolomics and Cell Therapy in Diabetes Mellitus. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2019;8(supp):41-48. Available from: https://sid.ir/paper/332264/en

    IEEE: Copy

    BAGHER LARIJANI, PARISA GOODARZI, MOLOUD PAYAB, Sepideh Alavi Moghadam, FAKHER RAHIM, NIKOO BANA, MINA ABEDI, Maryam Arabi, Hossein Adibi, and KAMBIZ GILANY, “Metabolomics and Cell Therapy in Diabetes Mellitus,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 8, no. supp, pp. 41–48, 2019, [Online]. Available: https://sid.ir/paper/332264/en

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