مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

HSV-TK Expressing Mesenchymal Stem Cells Exert Inhibitory Effect on Cervical Cancer Model

Pages

  146-153

Abstract

 A growing area of research is focused on cancer therapy, and new therapeutic approaches are welcomed. mesenchymal stem cell (MSC)-based gene therapy is a promising strategy in oncology. Intrinsic tropism and migration to tumor microenvironment with off lights are attractive features of this type of cell carrier. In this way, suicide genes have also found a good platform for better performance and have shown a stronger antitumor mechanism by riding on mesenchymal cells. In this study, we investigated the anti-tumor activity of intratumoral injected MSCs transduced with a lentivector expressing the HSV/TK in a mouse Cervical cancer model. Following the injection of MSCs transduced with lentivector carrying TK, MSCs alone or PBS into the mice tumor, ganciclovir was administered intraperitoneally during 14 days, and tumor size, survival time, natural killer (NK) cells and cytotoxic T lymphocyte (CTL) activities were assessed. We demonstrated that combination of suicide therapy and cell therapy leading m, to successful tumor inhibition. Significant reduction in tumor size was detected in test group in comparison with controls. Also, potent antitumor NK and CTL activity was seen in treatment group in comparison with controls. Our data demonstrated that the mesenchymal cells expressing TK had inhibitory effect on Cervical cancer model.

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    APA: Copy

    KENARKOOHI, AZRA, BAMDAD, TARAVAT, SOLEIMANI, MASOUD, SOLEIMANJAHI, HOORIEH, FALLAH, ALI, & FALAHI, SHAHAB. (2020). HSV-TK Expressing Mesenchymal Stem Cells Exert Inhibitory Effect on Cervical Cancer Model. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 9(2), 146-153. SID. https://sid.ir/paper/332288/en

    Vancouver: Copy

    KENARKOOHI AZRA, BAMDAD TARAVAT, SOLEIMANI MASOUD, SOLEIMANJAHI HOORIEH, FALLAH ALI, FALAHI SHAHAB. HSV-TK Expressing Mesenchymal Stem Cells Exert Inhibitory Effect on Cervical Cancer Model. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2020;9(2):146-153. Available from: https://sid.ir/paper/332288/en

    IEEE: Copy

    AZRA KENARKOOHI, TARAVAT BAMDAD, MASOUD SOLEIMANI, HOORIEH SOLEIMANJAHI, ALI FALLAH, and SHAHAB FALAHI, “HSV-TK Expressing Mesenchymal Stem Cells Exert Inhibitory Effect on Cervical Cancer Model,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 9, no. 2, pp. 146–153, 2020, [Online]. Available: https://sid.ir/paper/332288/en

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