مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

162
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

109
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

Increased Expression Level of Long Noncoding RNA H19 in Plasma of Patients with Myocardial Infarction

Pages

  122-129

Abstract

 long noncoding RNAs (lncRNAs) are lengthy noncoding transcripts which are actively involved in crucial cellular pathways. Tissue-specific expression of lncRNAs besides its secretion into the body fluids, has made lncRNAs in attention as biomarkers of the diseases. According to the role of lncRNAs, especially H19 in cardiac regeneration, it is not surprising if their altered expression levels lead to cardiac diseases. In the present study, the relative expression of H19 was compared in the plasma of atherosclerotic myocardial infarction and control individuals by real time-PCR, and data were normalized using GAPDH. The association of plasma level of lipid and homocystine with H19 expression was also considered. The potential of H19 to discriminate the case from control was studied using the ROC analysis. We found that the plasma level of H19 transcript significantly increased in the plasma of patients in comparison with the control group. Additionally, the relative expression level of H19 was directly associated with the plasma homocystine level. The relative expression of H19 at threshold of 0. 3 showed 70% sensitivity and 94% specificity to discriminate cases from controls. This study revealed that the expression level of H19 may be considered as a biomarker of myocardial infarction, although further studies are needed to generalize this finding.

Cites

References

Cite

APA: Copy

Safaei, Shokouh, TAHMASEBI BIRGANI, MARYAM, BIJANZADEH, MAHDI, & SEYEDIAN, SEYED MASOUD. (2020). Increased Expression Level of Long Noncoding RNA H19 in Plasma of Patients with Myocardial Infarction. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 9(2), 122-129. SID. https://sid.ir/paper/332290/en

Vancouver: Copy

Safaei Shokouh, TAHMASEBI BIRGANI MARYAM, BIJANZADEH MAHDI, SEYEDIAN SEYED MASOUD. Increased Expression Level of Long Noncoding RNA H19 in Plasma of Patients with Myocardial Infarction. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2020;9(2):122-129. Available from: https://sid.ir/paper/332290/en

IEEE: Copy

Shokouh Safaei, MARYAM TAHMASEBI BIRGANI, MAHDI BIJANZADEH, and SEYED MASOUD SEYEDIAN, “Increased Expression Level of Long Noncoding RNA H19 in Plasma of Patients with Myocardial Infarction,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 9, no. 2, pp. 122–129, 2020, [Online]. Available: https://sid.ir/paper/332290/en

Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button