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Information Journal Paper

Title

Effects of Pyrroloquinoline Quinone (PQQ) on Ischemia-Reperfusion Injury in Rat Ovaries: Histological and Biochemical Assessments

Pages

  35-40

Keywords

Pyrroloquinoline quinone (PQQ) 

Abstract

 Objective: To evaluate effects of pyrroloquinoline quinone (PQQ) on Ischemia-reperfusion injury using a rat Ovary model. Method: Thirty healthy female Wistar rats with 250g were randomized into five experimental groups (n=6): Group SHAM: The rats underwent only laparotomy. Group Ischemia: A 3-hour ischemia only. Group I/R: A 3-hour ischemia and a 3-hour reperfusion. 30 min before termination of reperfusion 20 μ L soybeen oil (Solvent of PQQ) was administered. Group I/PQQ: A 3-hour ischemia only and 20 μ L (10 mg/kg) Intraperitoneal administration (IP) of PQQ 2. 5 hours after induction of ischemia. Group I/R/PQQ: A 3-hour ischemia, a 3-hour reperfusion and 20 μ L (10 mg/kg) IP of PQQ 2. 5 hours after induction of ischemia. Results: Animals treated with PQQ showed significantly ameliorated development of ischemia and reperfusion tissue injury compared to those of other groups (p=0. 001). The significant higher values of SOD, GPO and GST were observed in I/R/PQQ animals compared to those of other groups (p=0. 001). Damage indicator (MDA) was significantly lower in I/R/PQQ animal compared to those of other groups (p=0. 001). Conclusion: Intraperitoneal administration of PQQ could be helpful in minimizing Ischemia-reperfusion injury in ovarian tissue exposed to ischemia.

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    APA: Copy

    Parhizkar, Pegah, MOHAMMADI, RAHIM, SHAHROOZ, RASOUL, & MOHAMMADI, VAHID. (2019). Effects of Pyrroloquinoline Quinone (PQQ) on Ischemia-Reperfusion Injury in Rat Ovaries: Histological and Biochemical Assessments. BULLETIN OF EMERGENCY AND TRAUMA BEAT, 7(1), 35-40. SID. https://sid.ir/paper/335210/en

    Vancouver: Copy

    Parhizkar Pegah, MOHAMMADI RAHIM, SHAHROOZ RASOUL, MOHAMMADI VAHID. Effects of Pyrroloquinoline Quinone (PQQ) on Ischemia-Reperfusion Injury in Rat Ovaries: Histological and Biochemical Assessments. BULLETIN OF EMERGENCY AND TRAUMA BEAT[Internet]. 2019;7(1):35-40. Available from: https://sid.ir/paper/335210/en

    IEEE: Copy

    Pegah Parhizkar, RAHIM MOHAMMADI, RASOUL SHAHROOZ, and VAHID MOHAMMADI, “Effects of Pyrroloquinoline Quinone (PQQ) on Ischemia-Reperfusion Injury in Rat Ovaries: Histological and Biochemical Assessments,” BULLETIN OF EMERGENCY AND TRAUMA BEAT, vol. 7, no. 1, pp. 35–40, 2019, [Online]. Available: https://sid.ir/paper/335210/en

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