مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Comparison of Ketamine-Propofol and Ketamine-Thiopental on Bispectral Index Values during Monitored Anesthesia Care (MAC) in Minor Traumatic Orthopedic Surgery; A Randomized, Double-Blind, Clinical Trial

Pages

  118-123

Abstract

 Objective: To compare the effects of Ketamine-Propofol and Ketamine-thiopental on bispectral index values during Monitored anesthesia care in minor orthopedic surgeries. Methods: This randomized double-blind clinical trial was performed on 90 patients undergoing minor orthopedic surgeries. Participants were randomly allocated to either groups of Propofol or thiopental. Bispectral index (BIS), non-invasive arterial blood pressure, SpO2, and electrocardiogram were monitored every 5 minutes. Patients in Propofol group received a bolus dose of 0. 5 mg/kg Ketamine, plus 0. 5 mg/kg Propofol. In thiopental group, patients received a bolus dose of 0. 5 mg/kg Ketamine, plus 50-75 mg thiopental. After the surgery, recovery duration, patients’ pain score (VAS) and any intra-operative recall or awareness were recorded. Statistical analysis was performed using SPSS version 19. 0 Results: BIS was lower in Ketamin-Propofol group (p<0. 001). Mean arterial blood pressure, heart rate and O2 saturation showed a significant difference between two groups (p<0. 001), which were lower in Ketamin– Propofol group. VAS score was higher in Ketamin-thiopental group (p<0. 001). Both groups were similar in intra-operative recall/awareness. Conclusion: Ketamine-Propofol combination deliver a better control over monitored anesthesia during surgery, providing lower BIS, higher O2 saturation and lower heart rate and arterial blood pressure in patients undergoing minor traumatic orthopedic surgeries.

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