THE EFFECT OF 8 WEEKS OF ENDURANCE TRAINING ON HYPOTHALAMIC NESFATIN-1 GENE EXPRESSION AND ITS CONCENTRATION IN MALE RATS

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GHANBARI NIAKI A.; HOSSEINPOUR F.; FATHI R.; SAFAI KENARI A.

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Journal: IRANIAN SOUTH MEDICAL JOURNAL (ISMJ) Year:2012 | Volume:15 | Issue:3 Page(s): 171-182

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Title

THE EFFECT OF 8 WEEKS OF ENDURANCE TRAINING ON HYPOTHALAMIC NESFATIN-1 GENE EXPRESSION AND ITS CONCENTRATION IN MALE RATS

Author(s)

GHANBARI NIAKI A. | HOSSEINPOUR F. | FATHI R. | SAFAI KENARI A. | Issue Writer Certificate

Keywords

NESFATIN-1Q2

NUCLEOBINDIN-2Q2

ANOREXIGENIC PROTEINQ2

GENE EXPRESSIONQ2

MALE RATQ2

Abstract

Background: Hypothalamus is mentioned as the major center of appetite and energy balance. Physical activity and the exersice are able to disturb the energy balance to negative. NESFATIN-1 is a regulating neuropeptide that is produced by hypothalamus and has an important role in establishing energy balance. The purpose of this study was to examine the effect of endurance training regimen on NESFATIN-1 GENE EXPRESSION and its concentration in the MALE RAT hypothalamus.Materials and Methods: Eleven adult wistar MALE RATs (8-10 week old, 130-145g) assigned into control (C, n=5) and training (E, n=6) groups. Training group was given exercise on a motor-driven treadmill (20 m/min, 0% grade, 60 min/session, 5 days/week for 8 weeks). Rats were sacrificed 72h after the last training session and then the hypothalamus tissue was excised for determination of NESFATIN-1 GENE EXPRESSION and its concentration by RT-PCR & ELIZA methods, respectively. Four hours before the experiment the food not tap water was removed from the animal cages. Data was analyzed by using an independent t-student test.Results: The current results indicated that the levels o f NESFATIN-1 GENE EXPRESSION and its concentration, ATP, and glycogen concentrations were non-significantly lower in trained group when compared with control group.Conclusion: This research showed for the first time, that a low-intensity exercises, decreases NESFATIN-1 expression and concentration in the hypothalamus, which accompanied insignificant reduction in energy source. It seems that in the present research, the exercise has had the same fasting and being hungry like effect on NESFATIN-1 expression and concentration in the hypothalamus.

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APA: Copy

GHANBARI NIAKI, A., HOSSEINPOUR, F., FATHI, R., & SAFAI KENARI, A.. (2012). THE EFFECT OF 8 WEEKS OF ENDURANCE TRAINING ON HYPOTHALAMIC NESFATIN-1 GENE EXPRESSION AND ITS CONCENTRATION IN MALE RATS. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 15(3), 171-182. SID. https://sid.ir/paper/33646/en

Vancouver: Copy

GHANBARI NIAKI A., HOSSEINPOUR F., FATHI R., SAFAI KENARI A.. THE EFFECT OF 8 WEEKS OF ENDURANCE TRAINING ON HYPOTHALAMIC NESFATIN-1 GENE EXPRESSION AND ITS CONCENTRATION IN MALE RATS. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)[Internet]. 2012;15(3):171-182. Available from: https://sid.ir/paper/33646/en

IEEE: Copy

A. GHANBARI NIAKI, F. HOSSEINPOUR, R. FATHI, and A. SAFAI KENARI, “THE EFFECT OF 8 WEEKS OF ENDURANCE TRAINING ON HYPOTHALAMIC NESFATIN-1 GENE EXPRESSION AND ITS CONCENTRATION IN MALE RATS,” IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), vol. 15, no. 3, pp. 171–182, 2012, [Online]. Available: https://sid.ir/paper/33646/en

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