EFFECT OF N-BUTANOL ON CHROMOSOMAL DAMAGE IN MICE BONE MARROW CELLS

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MANSOURI NAHID; HADDAD FARHANGH; FEREIDONI MASOUD; POURKAVEH BITA

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Journal: NOVELTY IN BIOMEDICINE Year:2016 | Volume:4 | Issue:3 Page(s): 110-115

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Title

EFFECT OF N-BUTANOL ON CHROMOSOMAL DAMAGE IN MICE BONE MARROW CELLS

Author(s)

MANSOURI NAHID | HADDAD FARHANGH | FEREIDONI MASOUD | POURKAVEH BITA | Issue Writer Certificate

Keywords

N-BUTANOL

CHROMOSOMAL DAMAGE

BONE MARROW CELLS

MICRONUCLEUS

Abstract

Background: N-BUTANOL is a four-carbon alcohol used widely in foods, cosmetics industries, biology and chemistry research laboratories, and other fields. Long time-effects of inhalation or consumption of small amounts of Butanol on human health are still unknown. On the other hand, numerous reports about the development of N-BUTANOL toxicity are available. The main objective of the study was to investigate the effects of inhaled and oral administration of N-BUTANOL as a long-term in vivo investigation.Materials and Methods: Small white laboratory, male mice (20-30 g) were used in 11 groups (n=4) including experimental 1 to 6, 1 to 4 control "A” and positive control groups. Experimental groups 1-3, for 10, 20, and 40 days; 5 hours a day were inside a box with ventilation facilities exposed to air saturated with N-BUTANOL vapor. Experimental groups 4 to 6, received water containing N-BUTANOL 0.2%, 1% and 5% for 10 days. Control groups B, 1 to 3 was placed for 10, 20, and 40 days inside a similar box exposed to normal air, respectively. Control group B 4 received water without any particular substance for 10 days. The positive control group received 30μl subcutaneous vinblastine. BONE MARROW CELLS were extracted 24 hours after treatments and stained by May-Grunwald-Giemsa staining and the number of MICRONUCLEUS was counted. Vinblastine, as a positive control, increased an average of MICRONUCLEUS numbers significantly compared to control group (P<0.001).Results: N-BUTANOL inhalation caused no significant difference in 1-3 experimental groups in the average numbers of MICRONUCLEUS compared to control group, even in the 40 days treatment group, average numbers of MICRONUCLEUS was decreased comparing to control group (P<0.05). Also, oral administration of 0.2% and 1% N-BUTANOL had no effect on the average MICRONUCLEUS numbers compared to the control group, while oral administration of 5% N-BUTANOL caused even decrease in average numbers of MICRONUCLEUS compared to control group (P<0.05).Conclusion: N-BUTANOL inhalation may not cause chromosome damages in rat BONE MARROW CELLS that probably is due to its very fast metabolism and decomposition in the body. Therefore, the amount of N-BUTANOL in the systemic circulation and tissues is very low and, probably, the damaging potential is decreased.

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APA: Copy

MANSOURI, NAHID, HADDAD, FARHANGH, FEREIDONI, MASOUD, & POURKAVEH, BITA. (2016). EFFECT OF N-BUTANOL ON CHROMOSOMAL DAMAGE IN MICE BONE MARROW CELLS. NOVELTY IN BIOMEDICINE, 4(3), 110-115. SID. https://sid.ir/paper/336604/en

Vancouver: Copy

MANSOURI NAHID, HADDAD FARHANGH, FEREIDONI MASOUD, POURKAVEH BITA. EFFECT OF N-BUTANOL ON CHROMOSOMAL DAMAGE IN MICE BONE MARROW CELLS. NOVELTY IN BIOMEDICINE[Internet]. 2016;4(3):110-115. Available from: https://sid.ir/paper/336604/en

IEEE: Copy

NAHID MANSOURI, FARHANGH HADDAD, MASOUD FEREIDONI, and BITA POURKAVEH, “EFFECT OF N-BUTANOL ON CHROMOSOMAL DAMAGE IN MICE BONE MARROW CELLS,” NOVELTY IN BIOMEDICINE, vol. 4, no. 3, pp. 110–115, 2016, [Online]. Available: https://sid.ir/paper/336604/en

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