Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

285
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

124
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

The Ameliorative Potential of Sophora alopecuroides Essential Oil on CCl4-Induced Hepatotoxicity in Mice; a Stereological Study

Pages

  47-54

Abstract

 Background and objectives: Sophora alopecuroides, one of the most important herbal medicines is widely grown in west of Iran, and has a long history for treatment of gastrointestinal diseases, leucorrhea, eczema, and psoriasis. The aim of this study was to investigate the ameliorative effect of Sophora alopecuroides essential oil on CCl4-induced hepatotoxicity in mice. Methods: Thirty five male mice were divided into five groups; group I as the negative control, received olive oil intraperitoneally and distilled water orally. Group II as the positive control, received CCl4 mixed with olive oil in the ratio of 5: 5, intraperitoneally and distilled water orally. Group III, IV and V received CCl4 and 200, 800 and 1600 μ g/kg of S. alopecuroides essential oil through gavages for 45 consecutive days. Results: The results showed that low and intermediate doses of S. alopecuroides essential oil significantly decreased the raised levels of Alanine aminotrasferase and Aspartate aminotransaminase toward control levels (p<0. 05). Alkaline phosphatase was improved with tree examined doses of S. alopecuroides essential oil. The volume and weight of the liver, as well as the volume of hepatocytes and sinusoids which had increased significantly in the positive control group (p<0. 05), decreased significantly following treatment by low dose of S. alopecuroides essential oil (p<0. 05). Conclusion: It was concluded that although Sophora alopecuroides essential could protect liver against CCl4-induced toxicity at lower doses, further studies would be needed to define the selective dose of this plant against CCl4-induced hepatotoxicity.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    GOODARZI, N., Doorgard, e., & POURNAGHI, P.. (2018). The Ameliorative Potential of Sophora alopecuroides Essential Oil on CCl4-Induced Hepatotoxicity in Mice; a Stereological Study. RESEARCH JOURNAL OF PHARMACOGNOSY, 5(1), 47-54. SID. https://sid.ir/paper/336801/en

    Vancouver: Copy

    GOODARZI N., Doorgard e., POURNAGHI P.. The Ameliorative Potential of Sophora alopecuroides Essential Oil on CCl4-Induced Hepatotoxicity in Mice; a Stereological Study. RESEARCH JOURNAL OF PHARMACOGNOSY[Internet]. 2018;5(1):47-54. Available from: https://sid.ir/paper/336801/en

    IEEE: Copy

    N. GOODARZI, e. Doorgard, and P. POURNAGHI, “The Ameliorative Potential of Sophora alopecuroides Essential Oil on CCl4-Induced Hepatotoxicity in Mice; a Stereological Study,” RESEARCH JOURNAL OF PHARMACOGNOSY, vol. 5, no. 1, pp. 47–54, 2018, [Online]. Available: https://sid.ir/paper/336801/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top