Alteration of Depressive-like Behaviors by Psilocybe cubensis Alkaloid Extract in Mice: the Role of Glutamate Pathway

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Mahmoudi Elaheh; FAIZI MEHRDAD; HAJIAGHAEE REZA; RAZMI ALI

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Journal Paper

Paper Information

Journal: RESEARCH JOURNAL OF PHARMACOGNOSY Year:2018 | Volume:5 | Issue:2 Page(s): 17-24

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Information Journal Paper

Title

Alteration of Depressive-like Behaviors by Psilocybe cubensis Alkaloid Extract in Mice: the Role of Glutamate Pathway

Author(s)

Mahmoudi Elaheh | FAIZI MEHRDAD | HAJIAGHAEE REZA | RAZMI ALI | Issue Writer Certificate

Keywords

anxiety

depression

NMDA receptor

Psilocybe cubensis

psilocybin

Abstract

Background and objectives: Considering the increasing prevalence of depression, many studies are launched to investigate new antidepressant treatments. The present research has shown how psilocybin as an active compound of Psilocybe cubensis (Earle) Singer extract (PCE) can change the parameters related to depression and anxiety in animal models. Both serotonin (5-hydroxytryptamine: 5-HT) and glutamate modulate depressive-like behaviors and, therefore, we examined the possible interaction of psilocybin as 5-HT1 agonist with glutamate receptor N-methyl-D-aspartate (NMDA). Methods: Psilocybe cubensis extract of this mushroom was prepared by ethyl acetate. NMRI mice involved in all experiments and were treated with the vehicle, extract, or standard drug intraperitoneally. Open field (OFT), forced swimming (FST) and tail suspension tests (TST) were applied to measure the intended parameters. OFT was performed to verify the applied doses for measuring the following antidepressant activity. Results: PCE at the doses of 100 mg/kg significantly changed the locomotion, time spent in center and velocity of the animals in OFT. While treatment of the animals with PCE 10 and 40 mg/kg or ketamine 1 mg/kg did not alter the locomotor activity, co-administration of these subeffective amounts significantly reduced the immobility time in both FST and TST. Conclusion: These effects may indicate possible implication of psilocybin with NMDA receptor which consequently produces the antidepressant effects.

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APA: Copy

Mahmoudi, Elaheh, FAIZI, MEHRDAD, HAJIAGHAEE, REZA, & RAZMI, ALI. (2018). Alteration of Depressive-like Behaviors by Psilocybe cubensis Alkaloid Extract in Mice: the Role of Glutamate Pathway. RESEARCH JOURNAL OF PHARMACOGNOSY, 5(2), 17-24. SID. https://sid.ir/paper/336820/en

Vancouver: Copy

Mahmoudi Elaheh, FAIZI MEHRDAD, HAJIAGHAEE REZA, RAZMI ALI. Alteration of Depressive-like Behaviors by Psilocybe cubensis Alkaloid Extract in Mice: the Role of Glutamate Pathway. RESEARCH JOURNAL OF PHARMACOGNOSY[Internet]. 2018;5(2):17-24. Available from: https://sid.ir/paper/336820/en

IEEE: Copy

Elaheh Mahmoudi, MEHRDAD FAIZI, REZA HAJIAGHAEE, and ALI RAZMI, “Alteration of Depressive-like Behaviors by Psilocybe cubensis Alkaloid Extract in Mice: the Role of Glutamate Pathway,” RESEARCH JOURNAL OF PHARMACOGNOSY, vol. 5, no. 2, pp. 17–24, 2018, [Online]. Available: https://sid.ir/paper/336820/en

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