INVESTIGATION OF E-CADHERIN EXPRESSION IN PERIPHERAL BLOOD OF PATIENTS WITH BREAST CANCER IN A POPULATION FROM SOUTHERN IRAN

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NAEIMI S.; ARDEKANI A.M.; GHADERI A.; ERFANI N.

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Journal: Iranian South Medical Journal Year:2015 | Volume:18 | Issue:1 Page(s): 117-124

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Title

INVESTIGATION OF E-CADHERIN EXPRESSION IN PERIPHERAL BLOOD OF PATIENTS WITH BREAST CANCER IN A POPULATION FROM SOUTHERN IRAN

Author(s)

NAEIMI S. | ARDEKANI A.M. | GHADERI A. | ERFANI N. | Issue Writer Certificate

Keywords

BREAST CANCERQ2

GENE EXPRESSIONQ2

E- CADHERINQ2

CELL -CELL ADHESIONQ2

Abstract

Background: BREAST CANCER is the most common malignancy in women, and is considered as the second causative factor in cancer mortality. E- CADHERIN is a trans member glycoprotein and play a essential role in cell-cell adhesion .It seems that E-cadherin GENE EXPRESSION can plays a role in suppressor of invasion and metastasis tumor. The aim of this study was to evaluate the correlation of E-cadherin GENE EXPRESSION with BREAST CANCER in the women population of southern Iran.Materials and Methods: 30 patients and 30 healthy individuals as control participated in this case-control study. mRNA extracted from peripheral blood. Real Time PCR technique was used to determine the GENE EXPRESSION. The statistical analysis was performed by the software SPSS and Mannwithny test.Results: The results indicated that there is no significant difference in level of E- CADHERIN GENE EXPRESSION in patients with BREAST CANCER and the control group (Pv>0.05). Furthermore, we found no significant correlation between the E- CADHERIN GENE EXPRESSION with the clinic pathological factors in the patients.Conclusion: it seems that E- CADHERIN GENE EXPRESSION plays no important role in increasing the susceptibility of women to BREAST CANCER in the population of southern Iran.

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APA: Copy

NAEIMI, S., ARDEKANI, A.M., GHADERI, A., & ERFANI, N.. (2015). INVESTIGATION OF E-CADHERIN EXPRESSION IN PERIPHERAL BLOOD OF PATIENTS WITH BREAST CANCER IN A POPULATION FROM SOUTHERN IRAN. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 18(1), 117-124. SID. https://sid.ir/paper/33712/en

Vancouver: Copy

NAEIMI S., ARDEKANI A.M., GHADERI A., ERFANI N.. INVESTIGATION OF E-CADHERIN EXPRESSION IN PERIPHERAL BLOOD OF PATIENTS WITH BREAST CANCER IN A POPULATION FROM SOUTHERN IRAN. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)[Internet]. 2015;18(1):117-124. Available from: https://sid.ir/paper/33712/en

IEEE: Copy

S. NAEIMI, A.M. ARDEKANI, A. GHADERI, and N. ERFANI, “INVESTIGATION OF E-CADHERIN EXPRESSION IN PERIPHERAL BLOOD OF PATIENTS WITH BREAST CANCER IN A POPULATION FROM SOUTHERN IRAN,” IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), vol. 18, no. 1, pp. 117–124, 2015, [Online]. Available: https://sid.ir/paper/33712/en

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