The Effect of Melatonin on Pediatric Drug-Resistant Epilepsy; a Randomized Double Blind Clinical Trial

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AKHONDIAN JAVAD; BEIRAGHI TOOSI MEHRAN; KIANIFAR HAMID REZA; TALEBI SAEEDEH; GHANAEI OMID

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Journal: Journal of Pediatric Perspectives Year:2016 | Volume:4 | Issue:11 (35) Page(s): 3897-3906

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Title

The Effect of Melatonin on Pediatric Drug-Resistant Epilepsy; a Randomized Double Blind Clinical Trial

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Keywords

Children

Intractable seizure

Melatonin

Abstract

Background About 15 to 40% of Children with seizures are refractory to standard anti-epileptic drugs and for such patients, other treatments such as surgery and the ketogenic diet can reduce seizure frequency. Melatonin is a natural pineal gland hormone. The use of Melatonin for controlling pediatric seizures is still controversial. This study aimed to evaluate the effect of Melatonin on seizures, parent's satisfaction, sleep, and behavior in Children with drug-resistant epilepsy. Materials and Methods: In a pilot crossover study, Children with drug-resistant epilepsy, who referred to the epileptic clinic of Ghaem Hospital, were randomly assigned to receive treatment with Melatonin or a placebo for 4 weeks followed by a one-day washout period. Then patients who started with Melatonin were switched to the placebo. Melatonin was administered 30 minutes before bedtime at a dose of 10 mg /m2 in 3mg tablets. Results Twenty patients, of which 11 (55%) were male, were enrolled into the study. The range and mean age of patients were 2 to 13 years and 7. 28 ± 3. 46 years, respectively. The mean number of diurnal seizures in the study group during placebo treatment was 11. 05 and during Melatonin treatment was 6. 25, which was statistically significant (P=0. 021). However, the reduction of the mean duration of diurnal seizures in the study groups was not statistically significant (P=0. 386). There was no correlation between decreasing in number or duration of seizures with Melatonin plasma levels. Drowsiness was the only side effect of Melatonin, which occurred in three patients. Conclusion Melatonin has probable beneficial effects on some epileptic patients with unclear mechanisms. Physicians can use it in selected epileptic Children to improve seizures.

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APA: Copy

AKHONDIAN, JAVAD, BEIRAGHI TOOSI, MEHRAN, KIANIFAR, HAMID REZA, TALEBI, SAEEDEH, & GHANAEI, OMID. (2016). The Effect of Melatonin on Pediatric Drug-Resistant Epilepsy; a Randomized Double Blind Clinical Trial. INTERNATIONAL JOURNAL OF PEDIATRICS, 4(11 (35)), 3897-3906. SID. https://sid.ir/paper/337221/en

Vancouver: Copy

AKHONDIAN JAVAD, BEIRAGHI TOOSI MEHRAN, KIANIFAR HAMID REZA, TALEBI SAEEDEH, GHANAEI OMID. The Effect of Melatonin on Pediatric Drug-Resistant Epilepsy; a Randomized Double Blind Clinical Trial. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2016;4(11 (35)):3897-3906. Available from: https://sid.ir/paper/337221/en

IEEE: Copy

JAVAD AKHONDIAN, MEHRAN BEIRAGHI TOOSI, HAMID REZA KIANIFAR, SAEEDEH TALEBI, and OMID GHANAEI, “The Effect of Melatonin on Pediatric Drug-Resistant Epilepsy; a Randomized Double Blind Clinical Trial,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 4, no. 11 (35), pp. 3897–3906, 2016, [Online]. Available: https://sid.ir/paper/337221/en

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