Glucose Oral Solution as A Pain-Relieving Agent In Infantile Colic: A Double Blinded Randomized Clinical Trial

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SHAHRAMIAN IRAJ; MORADI MANDANA; AFSHARI MAHDI; DELARAMNASAB MOJTABA; Ebrahimi Mahvash; SARGAZI ALIREZA; BAZI ALI

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Journal: Journal of Pediatric Perspectives Year:2017 | Volume:5 | Issue:12 (48) Page(s): 6529-6537

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Title

Glucose Oral Solution as A Pain-Relieving Agent In Infantile Colic: A Double Blinded Randomized Clinical Trial

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Keywords

Abdominal Cramps

Glucose

Infantile Colic

Simethicone

Abstract

Background Infantile Colic (IC) is a common painful disorder within early months of life. There is no definitive therapeutics for IC. In present study aimed to assess pain-relieving potential of Glucose administration in Infantile Colic. Materials and Methods This was a double blinded randomized clinical trial performed during May 2015-June 2017 in pediatric ward of Amir-Al-Momenin Hospital, Zabol city, Iran. Overall, 72 infants were randomly assigned to either Glucose or Simethicone groups (36 infants per group). Treatments were continued for 28 days with either 25% or 30% Glucose solution and 2. 5 mg/kg Simethicone. Outcomes were assessed at the end of the intervention (28 days). Statistical analysis was done in SPSS version 22. 0. Results Males and females constituted 20 (55. 5%), and 16 (45. 5%) in Glucose administrated, and 23 (63. 8%) and 13 (36. 2%, P=0. 4) in Simethicone group respectively. The mean age (days) was 19. 1± 3. 8 and 20. 2± 4. 9 for Glucose and Simethicone administrated groups, respectively (P=0. 2). The crying times per day significantly reduced in both groups (mean reduction in crying times of 3. 7± 2. 1, and 6. 3± 2. 1 hours in Glucose and Simethicone groups, respectively). Moreover, 25% and 44. 4% of infants in Glucose and Simethicone groups achieved ≥ 50% reduction in crying time, respectively (P=0. 06). According to the Glucose dose, infants who received 30% Glucose solution significantly revealed higher ratio of ≥ 50% reduction in crying time (47. 3%) than those received 25% Glucose solution in which no cases fulfilled this outcome (P<0. 0001). Conclusion Glucose may be a useful candidate to be considered as a pain-relieving agent in Infantile Colic.

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APA: Copy

SHAHRAMIAN, IRAJ, MORADI, MANDANA, AFSHARI, MAHDI, DELARAMNASAB, MOJTABA, Ebrahimi, Mahvash, SARGAZI, ALIREZA, & BAZI, ALI. (2017). Glucose Oral Solution as A Pain-Relieving Agent In Infantile Colic: A Double Blinded Randomized Clinical Trial. INTERNATIONAL JOURNAL OF PEDIATRICS, 5(12 (48)), 6529-6537. SID. https://sid.ir/paper/337502/en

Vancouver: Copy

SHAHRAMIAN IRAJ, MORADI MANDANA, AFSHARI MAHDI, DELARAMNASAB MOJTABA, Ebrahimi Mahvash, SARGAZI ALIREZA, BAZI ALI. Glucose Oral Solution as A Pain-Relieving Agent In Infantile Colic: A Double Blinded Randomized Clinical Trial. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2017;5(12 (48)):6529-6537. Available from: https://sid.ir/paper/337502/en

IEEE: Copy

IRAJ SHAHRAMIAN, MANDANA MORADI, MAHDI AFSHARI, MOJTABA DELARAMNASAB, Mahvash Ebrahimi, ALIREZA SARGAZI, and ALI BAZI, “Glucose Oral Solution as A Pain-Relieving Agent In Infantile Colic: A Double Blinded Randomized Clinical Trial,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 5, no. 12 (48), pp. 6529–6537, 2017, [Online]. Available: https://sid.ir/paper/337502/en

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