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Information Journal Paper

Title

The Survey of DBH Gene Polymorphism Rs5320 in Children with Attention Deficit Hyperactivity Disorder (ADHD)

Pages

  8177-8184

Abstract

 Background Attention deficit hyperactivity disorder (ADHD) is a common behavioral disorder that affects 8-12% of school-age children. Several environmental and genetic factors play a role in the etiology of this disease. One of the genetic factors involved is dopamine beta-hydroxylase (DBH) gene, which plays an essential role in catecholamine synthesis by converting dopamine into norepinephrine. Here we investigated DBH Polymorphisms associated with ADHD in North West of Iran. Materials and Methods: This descriptive comparative study was performed on 130 children aged 5-14 years who were diagnosed with ADHD by child and Adolescent psychiatrist following a detailed psychiatric assessment and 130 matching healthy children were also selected from local children’ s Hospital in Tabriz city, Iran. Also, 2ml Peripheral blood sample was obtained from all the participants and RFLP-PCR.technique was then used to study the Polymorphism position rs5320 and allele and genotype frequency of DBH gene. Results: The results showed that the frequency of allele A (as the allele causing the disorder) was 15% in ADHD subjects and 6% in healthy subjects (p <0. 05). The genotype frequency in ADHD subjects was 4%AA, 26%AG, and 70%GG, and 0%, 12% and 88% for healthy children, respectively (p=0. 017, do=2, χ 2=3. 14). Conclusion: The results suggest that DBH Polymorphism, position rs5320, plays a role in the pathogenicity of ADHD in the studied population and therefore can be considered as a candidate gene for future diagnosis.

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    APA: Copy

    AMIRI, SHAHROKH, TABATABAEI, SEYED MAHMOOD, ARFAIE, ASGHAR, Parvizi Aghdam, Maryam, BARZEGAR, HABIBEH, & MEHDIZADEH FANID, LEILA. (2018). The Survey of DBH Gene Polymorphism Rs5320 in Children with Attention Deficit Hyperactivity Disorder (ADHD). INTERNATIONAL JOURNAL OF PEDIATRICS, 6(9 (57)), 8177-8184. SID. https://sid.ir/paper/337575/en

    Vancouver: Copy

    AMIRI SHAHROKH, TABATABAEI SEYED MAHMOOD, ARFAIE ASGHAR, Parvizi Aghdam Maryam, BARZEGAR HABIBEH, MEHDIZADEH FANID LEILA. The Survey of DBH Gene Polymorphism Rs5320 in Children with Attention Deficit Hyperactivity Disorder (ADHD). INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2018;6(9 (57)):8177-8184. Available from: https://sid.ir/paper/337575/en

    IEEE: Copy

    SHAHROKH AMIRI, SEYED MAHMOOD TABATABAEI, ASGHAR ARFAIE, Maryam Parvizi Aghdam, HABIBEH BARZEGAR, and LEILA MEHDIZADEH FANID, “The Survey of DBH Gene Polymorphism Rs5320 in Children with Attention Deficit Hyperactivity Disorder (ADHD),” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 6, no. 9 (57), pp. 8177–8184, 2018, [Online]. Available: https://sid.ir/paper/337575/en

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