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Information Journal Paper

Title

Assessment of Serum Amino Acid Chromatography in Children with Inflammatory Bowel Diseases

Pages

  8853-8861

Abstract

 Background: Given the important role of amino acids in regulating many metabolic pathways of the body and considering the scarcity of markers for the diagnosis of Inflammatory bowel disease (IBD) and its differentiation, we aimed to investigate the status of Serum amino acids Chromatography in Children with IBD. Materials and Methods This case-control study was conducted among Children with primary diagnosis of IBD who referred to Mofid Children's hospital in Tehran, Iran. Children with a definite diagnosis of chronic IBD on the basis of endoscopy and biopsy were enrolled. In addition, 100 Children without any history of predisposing, chronic, or inflammatory disease who referred to the same hospital during the period of the study were also selected. All samples underwent Serum amino acids Chromatography via HPLC method. Results Of all the patients in the IBD group, 18 patients (18%) suffered from Crohn's disease and 82 patients (82%) had ulcerative colitis; the disease was active in 54 patients (54%). The results of Serum amino acids Chromatography showed that several amino acids were significantly higher in patients with IBD. Considering the normal serum levels of amino acids, only the levels of two amino acids of histidine and tryptophan were significantly different in the IBD group compared the control group. In total, of all the subjects, 30 Children (15%) had abnormal amino acid serum Chromatography; hence, its prevalence was significantly higher in the IBD group (P=0. 048). Conclusion The current study showed that serum amino acid Chromatography in Children with IBD were different from that in healthy Children. More specifically, the decrease in tryptophan level was more observed in patients with active disease.

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    APA: Copy

    IMANZADEH, FARID, EMADI, BATOOL, HOSSEINI, AMIRHOSSEIN, KHATAMI, KATAYOUN, DARA, NAGHI, OLANG, BEHESHTEH, & SAYYARI, ALIAKBAR. (2019). Assessment of Serum Amino Acid Chromatography in Children with Inflammatory Bowel Diseases. INTERNATIONAL JOURNAL OF PEDIATRICS, 7(1 (61)), 8853-8861. SID. https://sid.ir/paper/337593/en

    Vancouver: Copy

    IMANZADEH FARID, EMADI BATOOL, HOSSEINI AMIRHOSSEIN, KHATAMI KATAYOUN, DARA NAGHI, OLANG BEHESHTEH, SAYYARI ALIAKBAR. Assessment of Serum Amino Acid Chromatography in Children with Inflammatory Bowel Diseases. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2019;7(1 (61)):8853-8861. Available from: https://sid.ir/paper/337593/en

    IEEE: Copy

    FARID IMANZADEH, BATOOL EMADI, AMIRHOSSEIN HOSSEINI, KATAYOUN KHATAMI, NAGHI DARA, BEHESHTEH OLANG, and ALIAKBAR SAYYARI, “Assessment of Serum Amino Acid Chromatography in Children with Inflammatory Bowel Diseases,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 7, no. 1 (61), pp. 8853–8861, 2019, [Online]. Available: https://sid.ir/paper/337593/en

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