Low Bone Mineral Density and Associated Factors in Patients with Cystic Fibrosis: A Cross-Sectional Study

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Jafari Nodoushan Abdolhamid; GOLZAR AZAM; HASSANZAD MARYAM; SAYEDI SEYED JAVAD; VELAYATI ALIAKBAR

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Journal Paper

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Journal: Journal of Pediatric Perspectives Year:2017 | Volume:5 | Issue:7 (43) Page(s): 5237-5244

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Title

Low Bone Mineral Density and Associated Factors in Patients with Cystic Fibrosis: A Cross-Sectional Study

Author(s)

Keywords

Bone mineral density

Children

Cystic fibrosis

Dual-energy X-ray absorptiometry

Abstract

Background: Failure to maintain bone mass density is a major complication in patients with Cystic fibrosis (CF). This study was conducted to evaluate the prevalence of low Bone mineral density (BMD) and also identifying associated risk factors in CF patients. Materials and Methods: Present study conducted on 59 CF patients aged 5-35 years referred to respiratory clinic of Masih Daneshvari Hospital, Tehran-Iran. BMD was measured using dual energy X-ray absorptiometry (DXA) scan. Patients were divided in two groups: cases aged 5-18 years as group A and cases over 18 years as group B. Anthropometric variables, corticosteroid usage, pulmonary function test, serum calcium, phosphate and 25-OH vitamin D were assessed and correlation of them with BMD was investigated. Results: Low BMD (Z score <-2 standard deviation) was found in 72. 8% (44) of patients. There was a positive correlation between malnutrition, Forced Expiratory Volume 1 (FEV1) and BMD (r=59 and 0. 47, P<0. 01, respectively). Steroid therapy and Pseudomonas aeruginosa colonization correlated significantly inversely with BMD (r =-0. 34 and-0. 32, P<0. 05). Vitamin D deficiency was found in 36. 7% (18) CF patients. No significant correlation was found between 25-OH vitamin D levels and BMD (r = 0. 17; P=0. 23). Conclusion: In present study, the prevalence of low BMD was about 72. 8% with significant correlation with low weight, BMI (poor nutritional status), FEV1, Pseudomonas aeruginosa colonization and the use of glucocorticoids.

Cites

Cystic Fibrosis Patients Evaluation in the Last Decades in a Referral Center, Tehran-Iran

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APA: Copy

Jafari Nodoushan, Abdolhamid, GOLZAR, AZAM, HASSANZAD, MARYAM, SAYEDI, SEYED JAVAD, & VELAYATI, ALIAKBAR. (2017). Low Bone Mineral Density and Associated Factors in Patients with Cystic Fibrosis: A Cross-Sectional Study. INTERNATIONAL JOURNAL OF PEDIATRICS, 5(7 (43)), 5237-5244. SID. https://sid.ir/paper/337752/en

Vancouver: Copy

Jafari Nodoushan Abdolhamid, GOLZAR AZAM, HASSANZAD MARYAM, SAYEDI SEYED JAVAD, VELAYATI ALIAKBAR. Low Bone Mineral Density and Associated Factors in Patients with Cystic Fibrosis: A Cross-Sectional Study. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2017;5(7 (43)):5237-5244. Available from: https://sid.ir/paper/337752/en

IEEE: Copy

Abdolhamid Jafari Nodoushan, AZAM GOLZAR, MARYAM HASSANZAD, SEYED JAVAD SAYEDI, and ALIAKBAR VELAYATI, “Low Bone Mineral Density and Associated Factors in Patients with Cystic Fibrosis: A Cross-Sectional Study,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 5, no. 7 (43), pp. 5237–5244, 2017, [Online]. Available: https://sid.ir/paper/337752/en

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