Effect of Treatment with Vitamin D on Maternal and Neonatal Indices in Pregnant Women with Hypocalcemia: A Randomized Controlled Trial

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ABOTORABI SHOKOHOSSADAT; POOR HASHEMI SIMA; ESMAILZADEHHA NEDA; ZIAEE AMIR; KHOEINIHA MOHAMMAD HOSSEIN

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Journal Paper

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Journal: Journal of Pediatric Perspectives Year:2017 | Volume:5 | Issue:9 (45) Page(s): 5733-5739

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Title

Effect of Treatment with Vitamin D on Maternal and Neonatal Indices in Pregnant Women with Hypocalcemia: A Randomized Controlled Trial

Author(s)

Keywords

Body height

Body weight

Hypocalcemia

Pregnancy

Vitamin D deficiency

Abstract

Background The impact of concomitant Vitamin D deficiency and maternal Hypocalcemia on fetal growth has is not clear. The aim of this study was to determine the effect of treatment with vitamin D on maternal and neonatal indices in pregnant women with Hypocalcemia. Materials and Methods This clinical trial was conducted on 110 pregnant women (22-26 weeks of gestational age) with simultaneous mild Hypocalcemia (8 < serum calcium< 8. 5 mg/dL) and Vitamin D deficiency (25 (OH) D< 75 nmol/L). The study subjects were randomly allocated to intervention (n=55) and control (n=55) groups. In the control group, the subjects were given daily prenatal capsule until delivery. In the intervention group, the subjects were given 50, 000 Units vitamin D weekly for eight weeks in addition to prenatal capsules until delivery similar to the control group. At delivery, maternal calcium and 25 (OH) D level and neonatal indices (weight, height, and head circumference) were measured and compared between the groups. Results At delivery, mean maternal vitamin D level was 97. 5± 23. 4 nmol/L in the intervention group and 48. 9± 17. 2 nmol/L in the control group, respectively (P<0. 001). Mean maternal calcium level in the intervention group was higher than the control group (9. 0± 0. 6 mg/dl vs. 8. 8± 0. 5 mg/dl) but the difference was not statistically significant (P>0. 05). Mean neonatal weight, height, and head circumference were not significantly different between the two groups (P>0. 05). Conclusion In pregnant women with mild Hypocalcemia, treatment with vitamin D would not have effect on mean serum calcium and neonatal indices.

Cites

Effect of Vitamin D Supplementation on Vitamin D Levels of Term and Preterm Neonates and their Mothers: A Clinical Trial Study

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APA: Copy

ABOTORABI, SHOKOHOSSADAT, POOR HASHEMI, SIMA, ESMAILZADEHHA, NEDA, ZIAEE, AMIR, & KHOEINIHA, MOHAMMAD HOSSEIN. (2017). Effect of Treatment with Vitamin D on Maternal and Neonatal Indices in Pregnant Women with Hypocalcemia: A Randomized Controlled Trial. INTERNATIONAL JOURNAL OF PEDIATRICS, 5(9 (45)), 5733-5739. SID. https://sid.ir/paper/337818/en

Vancouver: Copy

ABOTORABI SHOKOHOSSADAT, POOR HASHEMI SIMA, ESMAILZADEHHA NEDA, ZIAEE AMIR, KHOEINIHA MOHAMMAD HOSSEIN. Effect of Treatment with Vitamin D on Maternal and Neonatal Indices in Pregnant Women with Hypocalcemia: A Randomized Controlled Trial. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2017;5(9 (45)):5733-5739. Available from: https://sid.ir/paper/337818/en

IEEE: Copy

SHOKOHOSSADAT ABOTORABI, SIMA POOR HASHEMI, NEDA ESMAILZADEHHA, AMIR ZIAEE, and MOHAMMAD HOSSEIN KHOEINIHA, “Effect of Treatment with Vitamin D on Maternal and Neonatal Indices in Pregnant Women with Hypocalcemia: A Randomized Controlled Trial,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 5, no. 9 (45), pp. 5733–5739, 2017, [Online]. Available: https://sid.ir/paper/337818/en

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